Morell Garcia, DanielRamos-Chavarino, DavidBauça, Josep MiquelArgente del Castillo, PaulaBallesteros-Vizoso, Maria AntonietaGarcía de Guadiana-Romualdo, LuisGomez-Cobo, CristinaAlbert Pou, JAmezaga-Menendez, RocioAlonso-Fernandez, AlbertoLlompart, IsabelGarcia-Raja, Ana2024-09-182024-09-182021-05-27Morell-Garcia D, Ramos-Chavarino D, Bauca JM, del Castillo PA, Ballesteros-Vizoso MA, de Guadiana-Romualdo LG, et al. Urine biomarkers for the prediction of mortality in COVID-19 hospitalized patients. Sci Rep. 2021 May 27;11(1):11134.2045-2322https://hdl.handle.net/20.500.13003/19888https://hdl.handle.net/20.500.12105/23322Risk factors associated with severity and mortality attributable to COVID-19 have been reported in different cohorts, highlighting the occurrence of acute kidney injury (AKI) in 25% of them. Among other, SARS-CoV-2 targets renal tubular cells and can cause acute renal damage. The aim of the present study was to evaluate the usefulness of urinary parameters in predicting intensive care unit (ICU) admission, mortality and development of AKI in hospitalized patients with COVID-19. Retrospective observational study, in a tertiary care hospital, between March 1st and April 19th, 2020. We recruited adult patients admitted consecutively and positive for SARS-CoV-2. Urinary and serum biomarkers were correlated with clinical outcomes (AKI, ICU admission, hospital discharge and in-hospital mortality) and evaluated using a logistic regression model and ROC curves. A total of 199 COVID-19 hospitalized patients were included. In AKI, the logistic regression model with a highest area under the curve (AUC) was reached by the combination of urine blood and previous chronic kidney disease, with an AUC of 0.676 (95%CI 0.512-0.840; p=0.023); urine specific weight, sodium and albumin in serum, with an AUC of 0.837 (95% CI 0.766-0.909; p<0.001) for ICU admission; and age, urine blood and lactate dehydrogenase levels in serum, with an AUC of 0.923 (95%CI 0.866-0.979; p<0.001) for mortality prediction. For hospitalized patients with COVID-19, renal involvement and early alterations of urinary and serum parameters are useful as prognostic factors of AKI, the need for ICU admission and death.enghttp://creativecommons.org/licenses/by/4.0/Area Under CurveAgedAdultCritical CareHumansObservational Studies as TopicMiddle AgedPrognosisHospitalizationMaleSeverity of Illness IndexBiomarkersAcute Kidney InjuryFemaleRisk FactorsCOVID-19ROC CurveUrineLogistic ModelsRetrospective Studiesresearch articleAttribution 4.0 International340455301111113410.1038/s41598-021-90610-yScientific Reportsopen accessModelos LogísticosLesión Renal AgudaBiomarcadoresOrinaFemeninoEstudios Observacionales como AsuntoCOVID-19HospitalizaciónMasculinoFactores de RiesgoHumanosPersona de Mediana EdadCuidados CríticosPronósticoAncianoÍndice de Severidad de la EnfermedadEstudios RetrospectivosAdultoÁrea Bajo la CurvaCurva ROC2-s2.0-85107015247658389400049L635191894