Guzman-Fulgencio, MariaBerenguer, JuanGarcia-Alvarez, MonicaFernandez-Rodriguez, AmandaJimenez-Sousa, Maria AngelesAlvarez, EmilioMicheloud, DarielaLópez, Juan CarlosMiralles, PilarCosín, JaimeCatalán, PilarResino, Salvador2024-02-042024-02-042013-02J Infect. 2013 Feb;66(2):170-8.http://hdl.handle.net/20.500.12105/17449Objective: To evaluate the association of IL28B polymorphisms and severity of liver disease among human immunodeficiency virus (HIV)/hepatitis C virus (HCV) coinfected patients. Methods: We carried out a cross-sectional study on 223 patients. Liver biopsies were evaluated according to Metavir score. IL28B polymorphisms (rs12980275, rs8099917, rs7248668, and rs11881222) were genotyped using GoldenGate(®) assay. Results: IL28B polymorphisms were in strong linkage disequilibrium, especially the couples rs12980275/rs11881222 and rs8099917/rs7248668. For all patients, the rs12980275 A allele increased the odds for significant fibrosis (F ≥ 2) odds ratio (OR) = 1.68; p = 0.018) and more rapid fibrosis progression (FPR ≥ 0.075 fibrosis units/year) (OR = 1.64; p = 0.035), and decreased the odds for liver steatosis (OR = 0.61; p = 0.046). Furthermore, the rs8099917 T allele increased the odds for F ≥ 2 (OR = 1.93; p = 0.020), FPR ≥ 0.075 (OR = 2.08; p = 0.021), and elevated ALT (≥80 IU/l) (OR = 1.78; p = 0.048). For HCV-genotype 1 patients, rs12980275 A and rs8099917 T alleles decreased the odds for liver steatosis (OR = 0.22; p < 0.001 and OR = 0.39; p = 0.048; respectively). For HCV-genotype 3 patients, the rs12980275 A allele increased the odds for F ≥ 2 ((OR = 6.30; p = 0.012), FPR ≥ 0.075 (OR = 6.40; p = 0.025), and elevated ALT (OR = 4.12; p = 0.037); and the rs8099917 T allele also increased the odds for F ≥ 2 (OR = 7.56; p = 0.027), FPR ≥ 0.075 (OR = 50.8; p = 0.012), and elevated ALT (OR = 5.39; p = 0.043). However, we did not find significant trends in patients infected with HCV-genotype 4. Conclusion: The major alleles of IL28B (rs12980275 A, rs11881222 A, rs8099917 T, and rs7248668 G) are associated with increased odds of liver disease severity in HIV patients infected with HCV-genotype 3. In contrast, HCV-genotype 1 patients carrying the major alleles of IL28B polymorphisms had lower odds for liver steatosis.engAMAIDSHepatitis CSNPsLiver biopsyFibrosisTransaminasesCoinfectionPolymorphism, Single NucleotideAdultAllelesCross-Sectional StudiesFemaleGene FrequencyGenotypeHIV InfectionsHepacivirusHepatitis C, ChronicHumansInterferonsInterleukinsLinkage DisequilibriumLiverMaleMiddle AgedSeverity of Illness IndexYoung AdultAttribution-NonCommercial-NoDerivatives 4.0 Internacional23103287662170-17810.1016/j.jinf.2012.10.0251532-2742The Journal of infectionopen access