Lope Carvajal, VirginiaGuerrero-Zotano, ÁngelFernandez de Larrea-Baz, NereaAntolín, SilviaBenavent Viñuales, MartaBermejo, BegoñaRuiz Moreno, EmmaBaena-Cañada, José ManuelParís, LorenaAntón, AntonioChacón, José IgnacioMuñoz, MontserratGarcía-Sáenz, José ÁngelOlier, ClaraSánchez Rovira, PedroArcusa Lanza, AngelsGonzález, SoniaBrunet, JoanOltra, AmparoBezares, SusanaRosell, LibertadPerez-Gomez, BeatrizPastor-Barriuso, RobertoMartín, MiguelPollan-Santamaria, Marina2024-10-302024-10-302024-08J Nutr Health Aging. 2024 Aug;28(8):100312.https://hdl.handle.net/20.500.12105/25375Objectives: Adherence to healthy lifestyle recommendations has been reported to improve health-related quality of life (HRQL) in breast cancer (BC) patients, but the influence of long-term behavioral changes remains unknown. We evaluated the association between adherence to the 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) cancer prevention recommendations and HRQL both, at BC diagnosis and the change 7-12 years later. Design: Prospective cohort study. Settings and participants: A total of 406 breast cancer survivors, from the EpiGEICAM study, were recruited in 16 Spanish hospitals. Measurements: Epidemiological, clinical, dietary, physical activity and HRQL information was collected both at recruitment and 7-12 years later. A 7-item score to measure compliance with recommendations was assessed according to the 2018 WCRF/AICR scoring criteria. HRQL was evaluated using SF-36 questionnaire. Linear mixed models for longitudinal data were used to assess the cross-sectional and longitudinal association between adherence score and the physical and mental component summary scores. Results: At diagnosis, for each unit increase in WCRF/AICR score adherence, the HRQL physical domain increased 0.78 points (95%CI: -0.04 to 1.60; P trend:0.06). The mean change in physical HRQL from diagnosis to follow-up per unit increase in within-subject adherence score was 0.73 points (95%CI: -0.18 to 1.65; P trend: 0.12). For the mental domain, no association was observed with compliance with the recommendations at diagnosis, nor with changes in adherence over time. Conclusions: Our results suggest that Increased adherence to WCRF/AICR cancer prevention recommendations over time could contribute to slightly improved long-term physical HRQoL in BC survivors.engVoRhttp://creativecommons.org/licenses/by-nc-nd/4.0/Breast cancer survivorsCancer prevention guidelinesHealth behaviorsHealth-related quality of lifeWCRF/AICR recommendationsAgedBreast NeoplasmsCancer SurvivorsCross-Sectional StudiesExerciseFemaleHealthy LifestyleHumansLongitudinal StudiesMiddle AgedPatient ComplianceProspective StudiesQuality of LifeSpainSurveys and QuestionnairesAttribution-NonCommercial-NoDerivatives 4.0 International3897084928810031210.1016/j.jnha.2024.1003121760-4788The Journal of nutrition, health and agingopen access