Jiang, XiaFinucane, Hilary KSchumacher, Fredrick RSchmit, Stephanie LTyrer, Jonathan PHan, YounghunMichailidou, KyriakiLesseur, CorinaKuchenbaecker, Karoline BDennis, JoeConti, David VCasey, GrahamGaudet, Mia MHuyghe, Jeroen RAlbanes, DemetriusAldrich, Melinda CAndrew, Angeline SAndrulis, Irene LAnton-Culver, HodaAntoniou, Antonis CAntonenkova, Natalia NArnold, Susanne MAronson, Kristan JArun, Banu KBandera, Elisa VBarkardottir, Rosa BBarnes, Daniel RBatra, JyotsnaBeckmann, Matthias WBenitez, JavierBenlloch, SaraBerchuck, AndrewBerndt, Sonja IBickeböller, HeikeBien, Stephanie ABlomqvist, CarlBoccia, StefaniaBogdanova, Natalia VBojesen, Stig EBolla, Manjeet KBrauch, HiltrudBrenner, HermannBrenton, James DBrook, Mark NBrunet, JoanBrunnström, HansBuchanan, Daniel DBurwinkel, BarbaraButzow, RalfCadoni, GabriellaCaldés, TrinidadCaligo, Maria ACampbell, IanCampbell, Peter TCancel-Tassin, GéraldineCannon-Albright, LisaCampa, DanieleCaporaso, NeilCarvalho, André LChan, Andrew TChang-Claude, JennyChanock, Stephen JChen, ChuChristiani, David CClaes, Kathleen B MClaessens, FrankClements, JudithCollée, J MargrietCorrea, Marcia CruzCouch, Fergus JCox, AngelaCunningham, Julie MCybulski, CezaryCzene, KamilaDaly, Mary BdeFazio, AnnaDevilee, PeterDiez, OrlandGago-Dominguez, ManuelaDonovan, Jenny LDörk, ThiloDuell, Eric JDunning, Alison MDwek, MiriamEccles, Diana MEdlund, Christopher KEdwards, Digna R VelezEllberg, CarolinaEvans, D GarethFasching, Peter AFerris, Robert LLiloglou, TriantafillosFigueiredo, Jane CFletcher, OliviaFortner, Renée TFostira, FlorentiaFranceschi, SilviaFriedman, EitanGallinger, Steven JGanz, Patricia AGarber, JudyGarcía-Sáenz, José AGayther, Simon AGiles, Graham GGodwin, Andrew KGoldberg, Mark SGoldgar, David EGoode, Ellen LGoodman, Marc TGoodman, GaryGrankvist, KjellGreene, Mark HGronberg, HenrikGronwald, JacekGuénel, PascalHåkansson, NiclasHall, PerHamann, UteHamdy, Freddie CHamilton, Robert JHampe, JochenHaugen, AageHeitz, FlorianHerrero, RolandoHillemanns, PeterHoffmeister, MichaelHøgdall, EstridHong, Yun-ChulHopper, John LHoulston, RichardHulick, Peter JHunter, David JHuntsman, David GIdos, GregoryImyanitov, Evgeny NIngles, Sue AnnIsaacs, ClaudineJakubowska, AnnaJames, PaulJenkins, Mark AJohansson, MattiasJohansson, MikaelJohn, Esther MJoshi, Amit DKaneva, RadkaKarlan, Beth YKelemen, Linda EKühl, TabeaKhaw, Kay-TeeKhusnutdinova, ElzaKibel, Adam SKiemeney, Lambertus AKim, JeriKjaer, Susanne KKnight, Julia AKogevinas, ManolisKote-Jarai, ZsofiaKoutros, StellaKristensen, Vessela NKupryjanczyk, JolantaLacko, MartinLam, StephanLambrechts, DietherLandi, Maria TeresaLazarus, PhilipLe, Nhu DLee, EunjungLejbkowicz, FlavioLenz, Heinz-JosefLeslie, GoskaLessel, DavorLester, JennyLevine, Douglas ALi, LiLi, Christopher ILindblom, AnnikaLindor, Noralane MLiu, GeoffreyLoupakis, FotiosLubiński, JanMaehle, LoviseMaier, ChristianeMannermaa, ArtoMarchand, Loic LeMargolin, SaraMay, TaymaaMcGuffog, LesleyMeindl, AlfonsMiddha, PoojaMiller, AustinMilne, Roger LMacInnis, Robert JModugno, FrancesmaryMontagna, MarcoMoreno, VictorMoysich, Kirsten BMucci, LoreleiMuir, KennethMulligan, Anna MarieNathanson, Katherine LNeal, David ENess, Andrew RNeuhausen, Susan LNevanlinna, HeliNewcomb, Polly ANewcomb, Lisa FNielsen, Finn CiliusNikitina-Zake, LieneNordestgaard, Børge GNussbaum, Robert LOffit, KennethOlah, EdithOlama, Ali Amin AlOlopade, Olufunmilayo IOlshan, Andrew FOlsson, HåkanOsorio, AnaPandha, HardevPark, Jong YPashayan, NoraParsons, Michael TPejovic, TanjaPenney, Kathryn LPeters, Wilbert H MPhelan, Catherine MPhipps, Amanda IPlaseska-Karanfilska, DijanaPring, MirandaProkofyeva, DaryaRadice, PaoloStefansson, KariRamus, Susan JRaskin, LeonRennert, GadRennert, Hedy Svan Rensburg, Elizabeth JRiggan, Marjorie JRisch, Harvey ARisch, AngelaRoobol, Monique JRosenstein, Barry SRossing, Mary AnneDe Ruyck, KimSaloustros, EmmanouilSandler, Dale PSawyer, Elinor JSchabath, Matthew BSchleutker, JohannaSchmidt, Marjanka KSetiawan, V WendyShen, HongbingSiegel, Erin MSieh, WeivaSinger, Christian FSlattery, Martha LSorensen, Karina DalsgaardSouthey, Melissa CSpurdle, Amanda BStanford, Janet LStevens, Victoria LStintzing, SebastianStone, JenniferSundfeldt, KarinSutphen, RebeccaSwerdlow, Anthony JTajara, Eloiza HTangen, Catherine MTardón, AdoninaTaylor, Jack ATeare, M DawnTeixeira, Manuel RTerry, Mary BethTerry, Kathryn LThibodeau, Stephen NThomassen, MadsBjørge, LineTischkowitz, MarcToland, Amanda ETorres, DianaTownsend, Paul ATravis, Ruth CTung, NadineTworoger, Shelley SUlrich, Cornelia MUsmani, NawaidVachon, Celine MVan Nieuwenhuysen, ElsVega, AnaAguado-Barrera, Miguel ElíasWang, QinWebb, Penelope MWeinberg, Clarice RWeinstein, StephanieWeissler, Mark CWeitzel, Jeffrey NWest, Catharine M LWhite, EmilyWhittemore, Alice SWichmann, H-ErichWiklund, FredrikWinqvist, RobertWolk, AlicjaWoll, PenellaWoods, MichaelWu, Anna HWu, XifengYannoukakos, DrakoulisZheng, WeiZienolddiny, ShanbehZiogas, ArgyriosZorn, Kristin KLane, Jacqueline MSaxena, RichaThomas, DuncanHung, Rayjean JDiergaarde, BrendaMcKay, JamesPeters, UlrikeHsu, LiGarcía-Closas, MontserratEeles, Rosalind AChenevix-Trench, GeorgiaBrennan, Paul JHaiman, Christopher ASimard, JacquesEaston, Douglas FGruber, Stephen BPharoah, Paul D PPrice, Alkes LPasaniuc, BogdanAmos, Christopher IKraft, PeterLindström, Sara2019-04-222019-04-222019-01-25Nat Commun. 2019;10(1):431.2041-1723http://hdl.handle.net/20.500.12105/7477Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 × 10-8), breast and ovarian cancer (rg = 0.24, p = 7 × 10-5), breast and lung cancer (rg = 0.18, p =1.5 × 10-6) and breast and colorectal cancer (rg = 0.15, p = 1.1 × 10-4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.engVoRhttp://creativecommons.org/licenses/by/4.0/Breast NeoplasmsCase-Control StudiesColorectal NeoplasmsEuropean Continental Ancestry GroupFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyAtribución 4.0 Internacional3068388010143110.1038/s41467-018-08054-42041-1723Nature communicationsopen access