Galindo-Albarrán, Ariel OLópez-Portales, Oscar HGutiérrez-Reyna, Darely YRodríguez-Jorge, OtonielSánchez-Villanueva, José AntonioRamírez-Pliego, OscarBergon, AurélieLoriod, BéatriceHolota, HélèneImbert, JeanHernández-Mendoza, ArmandoFerrier, PierreCarrillo-de-Santa-Pau, EnriqueValencia, AlfonsoSpicuglia, SalvatoreSantana, M Angélica2019-07-122019-07-122016-11-15Cell Rep. 2016;17(8):2151-2160.22111247http://hdl.handle.net/20.500.12105/7900To better understand why human neonates show a poor response to intracellular pathogens, we compared gene expression and histone modification profiles of neonatal naive CD8+ T cells with that of their adult counterparts. We found that neonatal lymphocytes have a distinct epigenomic landscape associated with a lower expression of genes involved in T cell receptor (TCR) signaling and cytotoxicity and a higher expression of genes involved in the cell cycle and innate immunity. Functional studies corroborated that neonatal CD8+ T cells are less cytotoxic, transcribe antimicrobial peptides, and produce reactive oxygen species. Altogether, our results show that neonatal CD8+ T cells have a specific genetic program biased toward the innate immune response. These findings will contribute to better diagnosis and management of the neonatal immune response.engVoRhttp://creativecommons.org/licenses/by-nc-sa/4.0/T lymphocyteEpigenomeHuman immunityImmune responseAdultCD8-Positive T-LymphocytesCytotoxicity, ImmunologicEpigenesis, GeneticGene Expression ProfilingGene Expression Regulation, DevelopmentalHumansImmunity, InnateInfant, NewbornTranscription FactorsAtribución-NoComercial-CompartirIgual 4.0 Internacional278519751782151-216010.1016/j.celrep.2016.10.0562211-1247Cell reportsopen access