Ibáñez-Sanz, GemmaDíez-Villanueva, AnnaAlonso, María HenarRodríguez-Moranta, FranciscoPerez-Gomez, BeatrizBustamante, MarionaMartín, VicenteLlorca, JavierAmiano, PilarArdanaz, EvaTardón, AdoninaJimenez-Moleon, Jose J.Peiró, RosanaAlguacil, JuanNavarro Rivas, CarmenGuinó, ElisabetBinefa, GemmaFernandez-Navarro, Pablo LEspinosa, AnnaDávila-Batista, VerónicaMolina, Antonio JoséPalazuelos, CamiloCastaño-Vinyals, GemmaAragones, NuriaKogevinas, ManolisMoreno, VictorPollan-Santamaria, Marina2018-11-212018-11-212017-02-24Sci Rep. 2017 Feb 24:7:43263.2045-2322http://hdl.handle.net/20.500.12105/6654Corrigendum: Risk Model for Colorectal Cancer in Spanish Population Using Environmental and Genetic Factors: Results from the MCC-Spain study. Sci Rep. 2017 May 17:7:46807. doi: 10.1038/srep46807. PMID: 28513606.Colorectal cancer (CRC) screening of the average risk population is only indicated according to age. We aim to elaborate a model to stratify the risk of CRC by incorporating environmental data and single nucleotide polymorphisms (SNP). The MCC-Spain case-control study included 1336 CRC cases and 2744 controls. Subjects were interviewed on lifestyle factors, family and medical history. Twenty-one CRC susceptibility SNPs were genotyped. The environmental risk model, which included alcohol consumption, obesity, physical activity, red meat and vegetable consumption, and nonsteroidal anti-inflammatory drug use, contributed to CRC with an average per factor OR of 1.36 (95% CI 1.27 to 1.45). Family history of CRC contributed an OR of 2.25 (95% CI 1.87 to 2.72), and each additional SNP contributed an OR of 1.07 (95% CI 1.04 to 1.10). The risk of subjects with more than 25 risk alleles (5th quintile) was 82% higher (OR 1.82, 95% CI 1.11 to 2.98) than subjects with less than 19 alleles (1st quintile). This risk model, with an AUROC curve of 0.63 (95% CI 0.60 to 0.66), could be useful to stratify individuals. Environmental factors had more weight than the genetic score, which should be considered to encourage patients to achieve a healthier lifestyle.engVoRhttp://creativecommons.org/licenses/by/4.0/Colorectal NeoplasmsEnvironmental ExposureGene FrequencyHumansModels, StatisticalPolymorphism, Single NucleotideRisk AssessmentSpainAtribución-4.0 Internacional2823381774326310.1038/srep432632045-2322Scientific Reportsopen access