de Miguel-Diez, JavierLopez-de-Andres, AnaJiménez-García, RodrigoPuente-Maestu, LuisJimenez-Trujillo, IsabelHernandez-Barrera, ValentinResino, SalvadorÁlvaro-Meca, Alejandro2018-03-192018-03-192016-11-15PLoS One. 2016 Nov 15;11(11):e0166421.1932-6203http://hdl.handle.net/20.500.12105/5748PURPOSE: The aim of this study was to estimate trends of incidence of hospital admissions and in-hospital mortality (IHM) in HIV-infected patients with COPD in the combination antiretroviral therapy (cART) era in Spain (1997-2012). METHODS: A retrospective study with data from nationwide population-based COPD diagnoses in the Spanish Minimum Basic Data Set (MBDS) was performed. We established groups according to their HIV and HCV infections: 1) HIV-uninfected patients; 2) HIV-infected patients (with or without HCV coinfection). RESULTS: 1,580,207 patients discharge with a COPD diagnosis were included in the study, 8902 of them were HIV-infected patients (5000 HIV-monoinfected patients and 3902 HIV/HCV-coinfected patients). The HIV-infected patients had higher incidence rates of hospital admissions for COPD than the HIV-uninfected patients during the study period. The HIV-monoinfected patients had higher rates of hospitalizations for COPD than the HIV/HCV-coinfected patients in the early-period cART (1997-1999), but these rates decreased in the first group and increased in the second, being even similar in both groups in the late-period cART (2004-2011). On the other hand, the HIV-infected patients with COPD had higher IHM than the HIV-uninfected patients with COPD. The mortality rates were higher in the HIV-monoinfected patients with COPD than in the HIV/HCV-coinfected patients with COPD in the early-period cART; however, in the late-period cART, the mortality rates trends seems higher in the HIV/HCV group. The likelihood of death in HIV/HCV-coinfected patients with COPD was similar to than in HIV-monoinfected patients with COPD. CONCLUSIONS: Incidence of hospital admissions for COPD and IHM have decreased among HIV-monoinfected individuals but have increased steadily among HIV/HCV-coinfected individuals in the cART era.engVoRhttp://creativecommons.org/licenses/by/4.0/AdultAntiretroviral Therapy, Highly ActiveAntiviral AgentsCoinfectionFemaleHIV InfectionsHepatitis C, ChronicHospital MortalityHospitalizationHumansIncidenceMaleMiddle AgedPulmonary Disease, Chronic ObstructiveRetrospective StudiesSpainSurvival AnalysisAtribución 4.0 Internacional278462971111e016642110.1371/journal.pone.01664211932-6203PLOS ONEopen access