Rodriguez-Galan, AnaFernandez-Messina, LolaSanchez-Madrid, Francisco2018-10-262018-10-262018Front Immunol. 2018; 9:21481664-3224http://hdl.handle.net/20.500.12105/6532MiRNA targeting of key immunoregulatory molecules fine-tunes the immune response. This mechanism boosts or dampens immune functions to preserve homeostasis while supporting the full development of effector functions. MiRNA expression changes during T cell activation, highlighting that their function is constrained by a specific spatiotemporal frame related to the signals that induce T cell-based effector functions. Here, we update the state of the art regarding the miRNAs that are differentially expressed during T cell stimulation. We also revisit the existing data on miRNA function in T cell activation, with a special focus on the modulation of the most relevant immunoregulatory molecules.engVoRhttp://creativecommons.org/licenses/by/4.0/T cell activationMicroRNAs (miRNAs)Immunoregulatory moleculesmiRNA signatureCD4CD8T lymphocyteEXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITISSYSTEMIC-LUPUS-ERYTHEMATOSUSMICRORNA-MEDIATED REGULATIONIMMUNE-RESPONSETGF-BETAMULTIPLE-SCLEROSISRNA-INTERFERENCEGENE-EXPRESSIONDOWN-REGULATIONCYTOKINE PRODUCTIONAtribución 4.0 Internacional30319616910.3389/fimmu.2018.02148Frontiers in Immunologyopen access