Ni, JiaqiNishi, Stephanie KBabio, NancyRos, EmilioBasterra-Gortari, F JavierCorella, DoloresCastañer, OMartínez, J AlfredoAlonso-Gómez, Ángel MWärnberg, JuliaVioque, JesusRomaguera, DoraLópez-Miranda, JoséEstruch, RamonTinahones, Francisco JSantos-Lozano, José ManuelSerra-Majem, LluisCano-Ibáñez, NaomiTur, Josep AFernández-García, José ManuelPintó, XavierDelgado-Rodriguez, MiguelMatía-Martín, PilarVidal, JosepVazquez, ClotildeDaimiel, LidiaFernández-Aranda, FernandoRuiz-Canela, MiguelMestres Solà, CristinaPortolés, OlgaSala-Vila, AleixGarcia-Rios, AntonioCompañ-Gabucio, Laura MaríaGómez-Gracia, EnriqueZulet, M AngelesChaplin, AliceCasas, RosaMartínez-Diz, SilviaTojal-Sierra, LucasGómez-Pérez, Ana MaríaToledo, EstefaníaRios, SantiagoOrtega-Azorín, Carolinade la Torre, RafaelPeña-Orihuela, Patricia JGarcia-de la Hera, ManuelaSayon-Orea, CarmenMalcampo, MireiaSalas-Salvado, JordiNi, JiaqiNishi, Stephanie KBabio, NancyRos, EmilioBasterra-Gortari, F JavierCorella, DoloresCastañer, OMartínez, J AlfredoAlonso-Gómez, Ángel MWärnberg, JuliaVioque, JesusRomaguera, DoraLópez-Miranda, JoséEstruch, RamonTinahones, Francisco JSantos-Lozano, José ManuelSerra-Majem, LluisCano-Ibáñez, NaomiTur, Josep AFernández-García, José ManuelPintó, XavierDelgado-Rodriguez, MiguelMatía-Martín, PilarVidal, JosepVazquez, ClotildeDaimiel, LidiaFernández-Aranda, FernandoRuiz-Canela, MiguelMestres Solà, CristinaPortolés, OlgaSala-Vila, AleixGarcia-Rios, AntonioCompañ-Gabucio, Laura MaríaGómez-Gracia, EnriqueZulet, M AngelesChaplin, AliceCasas, RosaMartínez-Diz, SilviaTojal-Sierra, LucasGómez-Pérez, Ana MaríaToledo, EstefaníaRios, SantiagoOrtega-Azorín, Carolinade la Torre, RafaelPeña-Orihuela, Patricia JGarcia-de la Hera, ManuelaSayon-Orea, CarmenMalcampo, MireiaSalas-Salvado, Jordi2024-10-092024-10-092023-06-01Ni J, Nishi SK, Babio N, Ros E, Basterra-Gortari FJ, Corella D, et al. Higher versus lower nut consumption and changes in cognitive performance over two years in a population at risk of cognitive decline: a cohort study. Am J Clin Nutr. 2023 Jun 1;https://hdl.handle.net/20.500.13003/19049https://hdl.handle.net/20.500.12105/23675Background: Tree nuts and peanuts (henceforth, nuts) are nutrient-dense foods rich in neuroprotective components; thus, their consumption could benefit cognitive health. However, evidence to date is limited and inconsistent regarding the potential benefits of nuts for cognitive function. Objective: To prospectively evaluate the association between nut consumption and 2-y changes in cognitive performance in older adults at cognitive decline risk. Methods: A total of 6,630 participants aged 55 to 75 y (mean age 65.0±4.9 y, 48.4% women) with overweight/obesity and metabolic syndrome completed a validated semi-quantitative food frequency questionnaire and a comprehensive battery of neuropsychological tests at baseline and a 2-y follow-up. Composite cognitive scores were used to assess global, general, attention, and executive function domains. Nut consumption was categorized as <1, ≥1 to <3, ≥3 to <7, and ≥7 servings/wk (1 serving=30 g). Multivariable-adjusted linear regression models were fitted to assess associations between baseline nut consumption and 2-y cognitive changes. Results: Nut consumption was positively associated with 2-y changes in general cognitive function (P-trend <0.001). Compared with participants consuming <1 serving/wk of nuts, those categorized as consuming ≥3 to <7 and ≥7 servings/wk showed more favorable changes in general cognitive performance (β z-score [95% CI] = 0.06 [0.00,0.12] and 0.13 [0.06,0.20], respectively). No significant changes were observed in the multivariable-adjusted models for other cognitive domains assessed. Conclusion: Frequent nut consumption was associated with a smaller decline in general cognitive performance over 2 y in older adults at risk of cognitive decline. Randomized clinical trials to verify our findings are warranted.enghttp://creativecommons.org/licenses/by-nc-nd/4.0/research articleAttribution-NonCommercial-NoDerivatives 4.0 Internacional3726990810.1016/j.ajcnut.2023.05.0321938-3207The American journal of clinical nutritionopen access2-s2.0-851634142781051859400001L641487889