García-Bujalance, SilviaNavarro-San Francisco, CarolinaRubio Muñoz, Jose MiguelArribas, José RamónGutierrez, Avelino2019-01-102019-01-102012-04-27Malar J. 2012 Apr 27;11:136.1475-2875http://hdl.handle.net/20.500.12105/6984As HIV becomes a chronic infection, an increasing number of HIV-infected patients are travelling to malaria-endemic areas. Association of malaria with HIV/AIDS can be clinically severe. Severe falciparum malaria is a medical emergency that is associated with a high mortality, even when treated in an Intensive Care Unit. This article describes two cases of HIV-positive patients, who returned from malaria-endemic areas and presented a parasitaemia > 5% of erythrocytes and clinical signs of severe falciparum malaria, both with > 350 CD4 cell count/μl, absence of chemoprophylaxis and successful response. Factors like drug interactions and the possible implication of anti-malarial therapy bioavailability are all especially interesting in HIV-malaria co-infections.engVoRhttp://creativecommons.org/licenses/by/2.0/AdultAntimalarialsCD4 Lymphocyte CountHIV InfectionsHumansMalaria, FalciparumMaleMiddle AgedParasitemiaPlasmodium falciparumTravelTreatment OutcomeAtribución 4.0 Internacional2254021411113610.1186/1475-2875-11-1361475-2875Malaria journalopen access