Oliván-Blázquez, BárbaraBona-Otal, MartaMéndez-López, FátimaLerma-Irureta, DavidGarcía-Izuel, PaulaIbáñez-Ruiz, JesúsMontolío, AlbertoRuiz-Herreros, MaríaGodino, JavierJimeno-Beltran, BeatrizEncabo-Berzosa, María Del MarArenaz, IzaskunMedel-Martínez, AnaCasado-Vicente, VerónicaCoiras, MayteTellería-Orriols, CarlosSchoorlemmer, JonMagallón-Botaya, Rosa2025-01-072025-01-072024-09-20Oliván-Blázquez B, Bona-Otal M, Méndez-López F, Lerma-Irureta D, García-Izuel P, Ibáñez-Ruiz J, Montolío A, Ruiz-Herreros M, Godino J, Jimeno-Beltran B, Encabo-Berzosa MDM, Arenaz I, Medel-Martínez A, Casado-Vicente V, Coiras M, Tellería-Orriols C, Schoorlemmer J, Magallón-Botaya R. Characterization model of the post COVID-19 condition based on immunological, biochemical, and cytokine markers. iScience. 2024 Aug 30;27(9):110839.https://hdl.handle.net/20.500.12105/25944This study was registered with ISRCTN Registry during recruitment (ISRCTN27312680).Post-coronavirus disease condition (PCC) continues to affect many people globally, yet there remains a lack of diagnostic biomarkers to distinguish PCC from those recovered from acute COVID-19. This study compared biomarkers between two age- and gender-matched groups: PCC individuals and those recovered within three months of acute COVID-19 in 2020 ( = 85 each). Biomarkers were assessed 12-24 months after initial diagnosis, examining biochemical profiles, blood cell counts, coagulation status, antibody serology, lymphocyte populations, and cytokine levels. PCC individuals exhibited significant alterations in 49 of 167 markers, including K+ levels, αGAD antibodies, antithrombin III, insulin-like growth factor-binding protein 3 (IGFBP3), and interleukin-10 (IL-10). A panel of αGAD, IL-10, potassium levels, and CD16CD56 cell presence distinguished PCC individuals from recovered patients with >88% accuracy and <92% precision.engVoRhttp://creativecommons.org/licenses/by-nc/4.0/BiochemistryImmunologyVirologyCharacterization model of the post COVID-19 condition based on immunological, biochemical, and cytokine markersAttribution-NonCommercial 4.0 International3931853427911083910.1016/j.isci.2024.1108392589-0042iScienceopen access