Molina, NoemiGonzález, AnaMonopoli, DonatoMentado, BelindaBecerra, JoséSantos-Ruiz, LeonorVida, YolandaPerez-Inestrosa, Ezequiel2024-02-122024-02-122020-04-01http://hdl.handle.net/10668/3530http://hdl.handle.net/20.500.12105/18022Osseointegration of metal prosthetic implants is a yet unresolved clinical need that depends on the interplay between the implant surface and bone cells. The lack of a relationship between bone cells and metal has traditionally been solved by coating the former with "organic" ceramics, such as hydroxyapatite. A novel approach is hereby presented, immobilizing covalently dendrimeric structures onto titanium implants. Amide-based amino terminal dendrons were synthetized and coupled to titanium surfaces in a versatile and controlled way. The dendritic moieties provide an excellent scaffold for the covalent immobilization of bioactive molecules, such as extracellular matrix (ECM) protein components or antibiotics. Herein, tripeptide arginine-glycine-aspartic acid (RGD) motifs were used to decorate the dendritic scaffolds and their influence on cell adhesion and proliferation processes was evaluated.engVoRhttp://creativecommons.org/licenses/by/4.0/Dendritic structuresTitanium implantsTripeptide arginine-glycine-aspartic acid (RGD) recognition patternMaterials testingCell adhesionTitanioOseointegraciónPrótesis e implantesEnsayo de materialesAdhesión celularDendrímerosOsseointegrationTitaniumAspartic AcidDendrimersCell AdhesionAttribution 4.0 International3224466510.3390/polym120407702073-4360Polymersopen access