Miarka, LauritzValiente, Manuel2024-12-042024-12-042021-11Neurooncol Adv . 2021 Nov 27;3(Suppl 5):v144-v156.https://hdl.handle.net/20.500.12105/25856Modeling of metastatic disease in animal models is a critical resource to study the complexity of this multi-step process in a relevant system. Available models of metastatic disease to the brain are still far from ideal but they allow to address specific aspects of the biology or mimic clinically relevant scenarios. We not only review experimental models and their potential improvements but also discuss specific answers that could be obtained from them on unsolved aspects of clinical management.Work in the Brain Metastasis Group is supported by Ministerio de Ciencia e Innovacion (SAF2017-89643-R) (M.V.), Fundacio La Marato de TV3 (141) (M.V.), Fundacion Ramon Areces (CIVP19S8163) (M.V.), Worldwide Cancer Research (19-0177) (M.V.), H2020-FETOPEN (828972) (M.V.), Cancer Research Institute (Clinic and Laboratory Integration Program CRI Award 2018 (54545)) (M.V.), Asociacion Espanola Contra el Cancer (GCTRA16015SEOA, LABAE19002VALI) (M.V.), European Research Council (ERC CoG 864759) (M.V.), and a Boehringer Ingelheim Fonds MD fellowship (L.M.). M.V. is an EMBO YIP member (4053).engVoRhttp://creativecommons.org/licenses/by-nc-nd/4.0/brain metastasisexperimental modelstherapytreatment toxicityAttribution-NonCommercial-NoDerivatives 4.0 International3485924135v144-v156Neurooncol Advopen access