Huertas, Jesus R.Casuso, Rafael A.Hernansanz-Agustín, PabloCogliati, Sara2019-07-042019-07-042019-06Oxid Med Cell Longev. 2019; 2019:70583501942-0900http://hdl.handle.net/20.500.12105/7853Skeletal muscles require the proper production and distribution ofenergy to sustain their work. To ensure this requirement is met, mitochondria form large networks within skeletal muscle cells, and during exercise, they can enhance their functions. In the present review, we discuss recent findings on exercise-induced mitochondrial adaptations. We emphasize the importance ofmitochondrial biogenesis, morphological changes, and increases in respiratory supercomplex formation as mechanisms triggered by exercise that may increase the function of skeletal muscles. Finally, we highlight the possible effects of nutraceutical compounds on mitochondrial performance during exercise and outline the use of exercise as a therapeutic tool in noncommunicable disease prevention. The resulting picture shows that the modulation of mitochondrial activity by exercise is not only fundamental for physical performance but also a key point for whole-organism well-being.engVoRhttp://creativecommons.org/licenses/by/4.0/Atribución 4.0 Internacional2019705835010.1155/2019/7058350Oxidative Medicine and Cellular Longevityopen access