Chin, Chee TangOng, Tiong KKrittayaphong, RungrojLee, Stephen W-LSawhney, Jitendra P SKim, Hyo-SooGarcia, Angeles AlonsoBueno, HectorPocock, Stuart JNhan, Vo TVega, AnaHayashi, NobuyaHuo, Yong2020-11-042020-11-042017-09-15Int J Cardiol. 2017; 243:15-20http://hdl.handle.net/20.500.12105/11284Many patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS) are medically managed without coronary revascularization. The reasons vary and may impact prognosis. EPICOR Asia (NCT01361386) is a prospective study of hospital survivors post-ACS enrolled in 218 hospitals from 8 countries/regions in Asia (06/2011-05/2012). All medically managed NSTE-ACS patients were classified into 3 groups: 1) no coronary angiography (CAG-); 2) non-significant coronary artery disease (CAD) on angiogram (CAG+ CAD-); and 3) significant CAD (CAG+ CAD+). We compared baseline differences between patients medically managed and patients undergoing revascularization, and also between the medically managed groups. Adverse events were reported and compared up to 2years. Of 6163 NSTE-ACS patients, 2272 (37%) were medically managed, with 1339 (59%), 254 (11%), and 679 (30%) in the CAG-, CAG+ CAD-, and CAG+ CAD+ groups, respectively. There were marked differences in the proportion of medically managed patients among the 8 countries/regions (13-81%). Medically managed patients had higher mortality at 2years compared with revascularization (8.7% vs. 3.0%, p<0.001). Among medically managed patients, CAG- patients were older, more likely to have pre-existing cardiovascular disease, and had the highest 2-year mortality (10.5% vs. 4.3% [CAG+ CAD-] and 6.6% [CAG+ CAD+], p<0.001). Mortality differences persisted after adjusting for other patient risk factors. Medically managed NSTE-ACS patients are a heterogeneous group with different risk stratification and variable prognosis. Identification of reasons underlying different management strategies, and key factors adversely influencing long-term prognosis, may improve outcomes.engAMhttp://creativecommons.org/licenses/by-nc-nd/4.0/Disease ManagementAcute Coronary SyndromeAgedAsiaFemaleFollow-Up StudiesHumansInternationalityMaleMiddle AgedNon-ST Elevated Myocardial InfarctionProspective StudiesRisk FactorsTreatment OutcomeAttribution-NonCommercial-NoDerivatives 4.0 Internacional2874702124315-2010.1016/j.ijcard.2017.04.059International journal of cardiologyopen access