Plasmodium falciparum pfhrp2 and pfhrp3 Gene Deletions in Malaria-Hyperendemic Region, South Sudan.

Molina-de la Fuente, IreneBenito, María José SagradoFlevaud, LaurenceOusley, JanetPasquale, Harriet AkelloJulla, AhmedAbdi, Abdirashid MChol, Buai TutAbubakr, BakriBenito, AgustínCasademont, CristianNanclares, CarolinaBerzosa, Pedro2026-01-222026-01-222023-01Molina-de la Fuente I, Benito MJS, Flevaud L, Ousley J, Pasquale HA, Julla A, Abdi AM, Chol BT, Abubakr B, Benito A, Casademont C, Nanclares C, Berzosa P. Plasmodium falciparum pfhrp2 and pfhrp3 Gene Deletions in Malaria-Hyperendemic Region, South Sudan. Emerg Infect Dis. 2023 Jan;29(1):154-159. doi: 10.3201/eid2901.220775. PMID: 36573593; PMCID: PMC9796199.https://hdl.handle.net/20.500.12105/27171Pfhrp2 and pfhrp3 gene deletions threaten the use of Plasmodium falciparum malaria rapid diagnostic tests globally. In South Sudan, deletion frequencies were 15.6% for pfhrp2, 20.0% for pfhrp3, and 7.5% for double deletions. Deletions were approximately twice as prevalent in monoclonal infections than in polyclonal infections.engVoRhttp://creativecommons.org/licenses/by/4.0/Plasmodium falciparumRDTSouth SudanDiagnosisHistidine-rich proteinMalariaMolecular epidemiologyParasitesSurveillanceVector-borne infectionsPlasmodium falciparum pfhrp2 and pfhrp3 Gene Deletions in Malaria-Hyperendemic Region, South Sudan.Attribution 4.0 International36573593291154-15910.3201/eid2901.220775Emerging Infectious Diseasesopen access