Lee, HyunShin, Sun HyeGu, SeonhyeZhao, DiKang, DanbeeJoi, Yeong RaeSuh, Gee YoungPastor-Barriuso, RobertoGuallar, EliseoCho, JuheePark, Hye Yun2020-04-232020-04-232018BMC Med . 2018 Oct 4;16(1):178.1741-7015http://hdl.handle.net/20.500.12105/9691BACKGROUND: Chronic obstructive pulmonary disease (COPD) is often accompanied by multiple comorbidities, which are associated with an increased risk of exacerbation, a poor health-related quality of life, and high mortality. However, differences in comorbidity profile by race and ethnicity in COPD patients have not been fully elucidated. METHODS: Participants aged 40 to 79 years with spirometry-defined COPD from the U.S. National Health and Nutrition Examination Survey (NHANES) (2007-2012) and from the Korea NHANES (2007-2015) were analyzed to compare the prevalence of comorbidities by race and ethnicity group. Comorbidities were defined using questionnaire data, physical exams, and laboratory tests. RESULTS: Non-Hispanic Whites had the highest prevalence of dyslipidemia (65.5%), myocardial infarction (6.2%), osteoarthritis (40.1%), and osteoporosis (13.6%), while non-Hispanic Blacks had the highest prevalence of asthma (24.0%), hypertension (70.2%), stroke (7.3%), diabetes mellitus (DM) (23.3%), anemia (16.4%), and rheumatoid arthritis (11.9%). Compared to non-Hispanic Whites, non-Hispanic Blacks had a significantly higher prevalence of hypertension, stroke, DM, anemia, and rheumatoid arthritis after adjusting for age, sex, body mass index, and smoking status, while Hispanics had a significantly higher prevalence of DM and anemia, and Koreans had significantly lower prevalences of all comorbidities except stroke, DM, and anemia. CONCLUSIONS: COPD-related comorbidities varied significantly by race and ethnicity, and different strategies may be required for the optimal management of COPD and its comorbidities in different race and ethnicity groups.engVoRhttp://creativecommons.org/licenses/by/4.0/COPDComorbidityEthnicityRaceAdultAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedNutrition SurveysPrevalencePulmonary Disease, Chronic ObstructiveQuality of LifeRepublic of KoreaUnited StatesComorbidityAtribución 4.0 Internacional3028585416117810.1186/s12916-018-1159-71741-7015BMC medicineopen access