Valiente, ManuelGarcía-Gómez, Pedro2022-10-212022-10-212020Tumor Vascularization. eds.Domenico Ribatti, Francesco Pezzella.London, Elsevier, 2020. En:Vascular co-option/ Pedro García Gomez, Manuel Valiente.a Zhu, Manuel Valiente. 2020, pags.33-47.978-0-12-819494-2http://hdl.handle.net/20.500.12105/15080Vascular co-option is an alternative mechanism to interact with blood vessels used by normal cells and hijacked by cancer cells. Functional experiments using in vivo models have demonstrated that co-option of pre-existing capillary networks is a critical step for the initiation of multiorgan metastases from different cancer types. Thus targeting this process pharmacologically is a very promising strategy to prevent metastases. Vascular co-option supports the viability of disseminated tumor cells, even when they remain dormant. Additionally, targeting vascular co-option could be a valuable strategy to challenge the emergence of resistance to more conventional therapies.engVoRvascular co-optioncapillariesMetastasisdormancyimmunosuppressionaggressivenessadhesionstemnessangiocrine factorshttps://doi.org/10.1016/C2019-0-00115-Xrestricted access