Fuertes, TeresaSalgado, Irenede Yebenes, Virginia G2021-10-152021-10-152021-04Front Immunol. 2021; 12:6604501664-3224http://hdl.handle.net/20.500.12105/13429Germinal centers (GCs) are complex multicellular structures in which antigen-specific B cells undergo the molecular remodeling that enables the generation of high-affinity antibodies and the differentiation programs that lead to the generation of plasma-antibody-secreting cells and memory B cells. These reactions are tightly controlled by a variety of mechanisms, including the post-transcriptional control of gene expression by microRNAs (miRNAs). Through the development of animal models with B cell-specific modified miRNA expression, we have contributed to the understanding of the role of miRNAs in the regulation of GC responses and in B cell neoplasia. Here, we review recent advances in the understanding of the role of miRNAs in the regulation of B cell and T follicular helper physiology during the GC response and in the diseases associated to GC response dysregulation.engVoRhttp://creativecommons.org/licenses/by/4.0/AnimalsB-LymphocytesCell DifferentiationGene Expression RegulationGerminal CenterHumansMiceMicroRNAsAtribución 4.0 Internacional339537211266045010.3389/fimmu.2021.660450Frontiers in immunologyopen access