Julibert, AliciaBibiloni, Maria Del MarBouzas, CristinaMartínez-González, Miguel ÁngelSalas-Salvadó, JordiCorella, DoloresZomeño, Maria DolorsRomaguera, DoraVioque, JesúsAlonso-Gómez, Ángel MWärnberg, JuliaMartínez, J AlfredoSerra-Majem, LuísEstruch, RamonTinahones, Francisco JLapetra, JoséPintó, XavierLopez-Miranda, JoséGarcía-Molina, LauraGaforio, José JuanMatía-Martín, PilarDaimiel, LidiaMartín-Sánchez, VicenteVidal, JosepVázquez, ClotildeRos, EmiliToledo, EstefaníaBecerra-Tomás, NereaPórtoles, OlgaPérez-Vega, Karla AFiol, MiquelTorres-Collado, LauraTojal-Sierra, LucasCarabaño-Moral, RosaAbete, ItziarSanchez-Villegas, AlmudenaCasas, RosaBernal-López, María RosaSantos-Lozano, José ManuelGalera, AnaUgarriza, LucíaRuiz-Canela, MiguelBabio, NancyColtell, OscarSchröder, HelmutKonieczna, JadwigaOrozco-Beltrán, DomingoSorto-Sánchez, CarolinaEguaras, SoniaBarrubés, LauraFitó, MontserratTur, Josep APredimed-Plus Investigators2024-02-102024-02-102019-06-29http://hdl.handle.net/10668/14204http://hdl.handle.net/20.500.13003/16097http://hdl.handle.net/20.500.12105/17884Background: The effect of dietary fat intake on the metabolic syndrome (MetS) and in turn on cardiovascular disease (CVD) remains unclear in individuals at high CVD risk. Objective: To assess the association between fat intake and MetS components in an adult Mediterranean population at high CVD risk. Design: Baseline assessment of nutritional adequacy in participants (n = 6560, men and women, 55-75 years old, with overweight/obesity and MetS) in the PREvención con DIeta MEDiterránea (PREDIMED)-Plus randomized trial. Methods: Assessment of fat intake (total fat, monounsatured fatty acids: MUFA, polyunsaturated fatty acids: PUFA, saturated fatty acids: SFA, trans-fatty acids: trans-FA, linoleic acid, α-linolenic acid, and ω-3 FA) using a validated food frequency questionnaire, and diet quality using 17-item Mediterranean dietary questionnaire and fat quality index (FQI). Results: Participants in the highest quintile of total dietary fat intake showed lower intake of energy, carbohydrates, protein and fiber, but higher intake of PUFA, MUFA, SFA, TFA, LA, ALA and ω-3 FA. Differences in MetS components were found according to fat intake. Odds (5th vs. 1st quintile): hyperglycemia: 1.3-1.6 times higher for total fat, MUFA, SFA and ω-3 FA intake; low high-density lipoprotein cholesterol (HDL-c): 1.2 higher for LA; hypertriglyceridemia: 0.7 lower for SFA and ω-3 FA intake. Conclusions: Dietary fats played different role on MetS components of high CVD risk patients. Dietary fat intake was associated with higher risk of hyperglycemia.engVoRMediterranean dietCardiovascular disease riskDietary fatFat intakeFatty acidsAgedBiomarkersBlood GlucoseCardiovascular DiseasesCross-Sectional StudiesDiet, MediterraneanDietary FatsDyslipidemiasFemaleHumansHyperglycemiaLipidsMaleMetabolic SyndromeMiddle AgedRisk AssessmentRisk FactorsSpainTreatment OutcomeAttribution 4.0 International3126196711710.3390/nu110714932072-6643Nutrientsopen accessDieta MediterráneaResultado del TratamientoBiomarcadoresSíndrome MetabólicoFemeninoGrasas de la DietaLípidosMasculinoEstudios TransversalesFactores de RiesgoDislipidemiasHumanosPersona de Mediana EdadGlucemiaHiperglucemiaAncianoMedición de RiesgoEnfermedades CardiovascularesEspaña2-s2.0-85069267692478885400086L2002354203