Valvi, DamaskiniCasas, MaribelRomaguera, DoraMonfort, NuriaVentura, RosaMartinez, DavidSunyer, JordiVrijheid, Martine2024-07-042024-07-042015-10Valvi D, Casas M, Romaguera D, Monfort N, Ventura R, Martinez D, et al. Prenatal Phthalate Exposure and Childhood Growth and Blood Pressure: Evidence from the Spanish INMA-Sabadell Birth Cohort Study. Environ Health Perspect. 2015 Oct;123(10):1022-9. Epub 2015 Apr 7.0091-6765http://hdl.handle.net/20.500.13003/10682http://hdl.handle.net/20.500.12105/20146BACKGROUND: Human evidence on the effects of early life phthalate exposure on obesity and cardiovascular disease risks, reported by experimental studies, is limited to a few cross-sectional studies. OBJECTIVES: We evaluated the associations between prenatal phthalate exposure and childhood growth and blood pressure in a Spanish birth cohort study. METHODS: We assessed exposure using the average of two phthalate metabolite spot-urine concentrations collected from the mothers in the first and third pregnancy trimesters (creatinine-adjusted, n = 391). Study outcomes were the difference in age-and sex-specific z-scores for weight between birth and 6 months of age; and repeated age-and sex-specific z-scores for body mass index (BMI) at 1, 4, and 7 years; waist-to-height ratio at 4 and 7 years; and age-and height-specific z-scores for systolic and diastolic blood pressure at 4 and 7 years. RESULTS: The sum of five high-molecular-weight phthalate metabolites (Sigma HMWPm) was associated with lower weight z-score difference between birth and 6 months (beta per doubling of exposure = -0.41; 95% CI: -0.75, -0.06) and BMI z-scores at later ages in boys (beta = -0.28; 95% CI: -0.60, 0.03) and with higher weight z-score difference (beta = 0.24; 95% CI: -0.16, 0.65) and BMI z-scores in girls (beta = 0.30; 95% CI: -0.04, 0.64) (p for sex interaction = 0.01 and 0.05, respectively). The sum of three low-molecular-weight phthalates (Sigma LMWPm) was not significantly associated with any of the growth outcomes. Sigma HMWPm and Sigma LMWPm were associated with lower systolic blood pressure z-scores in girls but not in boys. CONCLUSIONS: This study suggests that prenatal phthalate exposure may be associated with postnatal growth and blood pressure in a sex-specific manner. Inconsistencies with previous cross-sectional findings highlight the necessity for evaluating phthalate health effects in prospective studies.enghttp://creativecommons.org/licenses/by/4.0/ChildSpainAdultEnvironmental PollutantsHumansChild, PreschoolBlood PressureInfantPregnancyPhthalic AcidsWaist-Height RatioMaleInfant, NewbornProspective StudiesSex FactorsFemaleBody Mass IndexWeight GainPrenatal Exposure Delayed Effectsresearch articleAttribution 4.0 International25850106123101022-102910.1289/ehp.14088871552-9924Environmental Health Perspectivesopen accessÍndice de Masa CorporalAumento de PesoRecién NacidoFemeninoLactanteMasculinoContaminantes AmbientalesFactores SexualesPreescolarPresin SanguíneaHumanosRelación Cintura-EstaturaEstudios ProspectivosEmbarazoÁcidos FtálicosNiñoAdultoEfectos Tardíos de la Exposición PrenatalEspaña2-s2.0-84930638624366698200024L606301160