Arias-de la Rosa, IvánEscudero-Contreras, AlejandroRuiz-Ponce, MiriamCuesta-López, LauraRomán-Rodríguez, CristóbalPérez-Sánchez, CarlosRuiz-Limón, PatriciaRuiz, Rocío Guzman-Leiva-Cepas, FernandoAlcaide, JuanSegui, PedroPlasencia, ChamaidaMartinez-Feito, AnaFont, PilarÁbalos, María COrtega, RafaelaMalagón, María MTinahones, Francisco JCollantes-Estévez, EduardoLópez-Pedrera, CharyBarbarroja, Nuria2024-02-272024-02-272022-08-06http://hdl.handle.net/10668/22278http://hdl.handle.net/20.500.12105/18732We aimed to evaluate the association between adipose tissue (AT) dysfunction, autoimmunity, and disease activity in rheumatoid arthritis (RA). A cross-sectional study including 150 RA patients and 50 healthy donors and longitudinal study with 122 RA patients treated with anti-tumor necrosis factor (TNF)-α, anti-interleukin 6 receptor (IL6R) or anti-CD20 therapies for 6 months were carried out. In vitro experiments with human AT and adipocyte and macrophage cell lines were performed. A collagen-induced arthritis mouse model was developed. The insulin resistance and the altered adipocytokine profile were associated with disease activity, the presence of anti-citrullinated proteins anti-bodies (ACPAs), and worse response to therapy in RA. AT in the context of arthritis is characterized by an inflammatory state alongside the infiltration of macrophages and B/plasmatic cells, where ACPAs can have a direct impact, inducing inflammation and insulin resistance in macrophages and promoting a defective adipocyte differentiation, partially restored by biologicals.engVoRhttp://creativecommons.org/licenses/by-nc-nd/4.0/Health sciencesImmunologyRheumatologyAttribution-NonCommercial-NoDerivatives 4.0 International3604618925910489310.1016/j.isci.2022.1048932589-0042iScienceopen access