Aguado, José MaríaSilva, JTFernandez-Ruiz, MarioCordero, ElisaFortun, JesusGudiol, CMartinez-Martinez, LVidal, EAlmenar, LAlmirante, BCanton, RCarratala, JCaston, JJCercenado, ECervera, CCisneros, JMCrespo-Leiro, MGCuervas-Mons, VElizalde-Fernandez, JFarinas Alvarez, CarmenGavalda, JGoyanes, MJGutierrez-Gutierrez, BHernandez, DLen, OLopez-Andujar, RLopez-Medrano, FMartín-Dávila, PilarMontejo, MMoreno, AOliver, AntonioPascual, APérez-Nadales, ElenaRoman-Broto, ASan-Juan, RSeron, DSole-Jover, AValerio, MMunoz, PTorre-Cisneros, JSpanish Soc Transplantat SETGrp Study Infection Transplantat SSpanish Network Res Infe2024-09-062024-09-062018-01Aguado J. M., Silva J. T., Fernandez-Ruiz M., Cordero E., Fortun J., Gudiol C., et al. Management of multidrug resistant Gram-negative bacilli infections in solid organ transplant recipients: SET/GESITRA-SEIMC/REIPI recommendations. Transplant Rev. 2018 Jan;32(1):36-57. Epub 2017 Jul 26.0955-470Xhttp://hdl.handle.net/20.500.13003/9470https://hdl.handle.net/20.500.12105/22640Solid organ transplant (SOT) recipients are especially at risk of developing infections by multidrug resistant (MDR) Gram-negative bacilli (GNB), as they are frequently exposed to antibiotics and the healthcare setting, and are regulary subject to invasive procedures. Nevertheless, no recommendations concerning prevention and treatment are available. A panel of experts revised the available evidence; this document summarizes their recommendations: (1) it is important to characterize the isolate's phenotypic and genotypic resistance profile; (2) overall, donor colonization should not constitute a contraindication to transplantation, although active infected kidney and lung grafts should be avoided; (3) recipient colonization is associated with an increased risk of infection, but is not a contraindication to transplantation; (4) different surgical prophylaxis regimens are not recommended for patients colonized with carbapenem-resistant GNB; (5) timely detection of carriers, contact isolation precautions, hand hygiene compliance and antibiotic control policies are important preventive measures; (6) there is not sufficient data to recommend intestinal decolonization; (7) colonized lung transplant recipients could benefit from prophylactic inhaled antibiotics, specially for Pseudomonas aeruginosa; (8) colonized SOT recipients should receive an empirical treatment which includes active antibiotics, and directed therapy should be adjusted according to susceptibility study results and the severity of the infection.engAMhttp://creativecommons.org/licenses/by-nc-nd/4.0/Gram-Negative Bacterial InfectionsTissue DonorsAnti-Bacterial AgentsHumansPostoperative ComplicationsTransplant RecipientsDrug Resistance, MultipleOrgan TransplantationDisease ManagementAttribution-NonCommercial-NoDerivatives 4.0 International2881107432136-5710.1016/j.trre.2017.07.001Transplantation Reviewsopen accessTrasplante de órganosComplicaciones PosoperatoriasReceptores de TrasplantesManejo de la EnfermedadHumanosDonantes de TejidosAntibacterianosResistencia a Múltiples MedicamentosInfecciones por Bacterias Gramnegativas2-s2.0-85028328902419263200005L618020670