Sánchez-Villegas, AlmudenaÁlvarez-Pérez, JacquelineToledo, EstefaníaSalas-Salvadó, JordiOrtega-Azorín, CarolinaZomeño, Maria DoloresVioque, JesúsMartínez, Jose AlfredoRomaguera, DoraPérez-López, JessicaLópez-Miranda, JoséEstruch, RamónBueno-Cavanillas, AuroraArós, FernandoTur, Josep ATinahones, Francisco JLecea, OscarMartín, VicenteOrtega-Calvo, MVázquez, ClotildePintó, XavierVidal, JosepDaimiel, LidiaDelgado-Rodríguez, MiguelMatía, PilarCorella, DoloresDíaz-López, AndrésBabio, NancyMuñoz, Miguel ÁngelFitó, MontserratGarcía de la Hera, ManoliAbete, ItziarGarcía-Rios, AntonioRos, EmilioRuíz-Canela, MiguelMartínez-González, Miguel ÁngelIzquierdo, MarisolSerra-Majem, Lluis2024-02-082024-02-082018-12-18http://hdl.handle.net/10668/13332http://hdl.handle.net/20.500.13003/8986http://hdl.handle.net/20.500.12105/17648Background: The aim of this analysis was to ascertain the type of relationship between fish and seafood consumption, omega-3 polyunsaturated fatty acids (-3 PUFA) intake, and depression prevalence. Methods: Cross-sectional analyses of the PREDIMED-Plus trial. Fish and seafood consumption and -3 PUFA intake were assessed through a validated food-frequency questionnaire. Self-reported life-time medical diagnosis of depression or use of antidepressants was considered as outcome. Depressive symptoms were collected by the Beck Depression Inventory-II. Logistic regression models were used to estimate the association between seafood products and -3 PUFA consumption and depression. Multiple linear regression models were fitted to assess the association between fish and long-chain (LC) -3 PUFA intake and depressive symptoms. Results: Out of 6587 participants, there were 1367 cases of depression. Total seafood consumption was not associated with depression. The odds ratios (ORs) (95% confidence intervals (CIs)) for the 2nd, 3rd, and 4th quintiles of consumption of fatty fish were 0.77 (0.63-0.94), 0.71 (0.58-0.87), and 0.78 (0.64-0.96), respectively, and p for trend = 0.759. Moderate intake of total LC -3 PUFA (approximately 0.5-1 g/day) was significantly associated with a lower prevalence of depression. Conclusion: In our study, moderate fish and LC -3 PUFA intake, but not high intake, was associated with lower odds of depression suggesting a U-shaped relationship.engVoRhttp://creativecommons.org/licenses/by/4.0/DepressionDocosahexaenoic acidEicosapentaenoic acidFishOmega-3AgedAnimalsCross-Sectional StudiesDepressionDepressive DisorderDietDiet SurveysEnergy IntakeFatty Acids, Omega-3Feeding BehaviorFemaleFishesHumansLogistic ModelsMaleMiddle AgedOdds RatioPrevalenceSeafoodAttribution 4.0 International30567286101210.3390/nu101220002072-6643Nutrientsopen accessAnimalesModelos LogísticosOportunidad RelativaPrevalenciaAlimentos MarinosÁcidos Grasos Omega-3FemeninoDietaMasculinoConducta AlimentariaEncuestas sobre DietasPecesEstudios TransversalesHumanosPersona de Mediana EdadIngestión de EnergíaDepresiónAncianoEncuestas y CuestionariosTrastorno Depresivo2-s2.0-85058901912455073200181L625530871