Delgado-Sanz, ConcepcionMazagatos, ClaraOliva Dominguez, Jesus AngelGherasim, Alin ManuelLarrauri, Amparo2022-09-022022-09-022020-02Emerg Infect Dis. 2020 Feb;26(2):220-228.http://hdl.handle.net/20.500.12105/14929We conducted a retrospective cohort study to assess the effect of influenza virus type and subtype on disease severity among hospitalized influenza patients in Spain. We analyzed the cases of 8,985 laboratory-confirmed case-patients hospitalized for severe influenza by using data from a national surveillance system for the period 2010-2017. Hospitalized patients with influenza A(H1N1)pdm09 virus were significantly younger, more frequently had class III obesity, and had a higher risk for pneumonia or acute respiratory distress syndrome than patients infected with influenza A(H3N2) or B (p<0.05). Hospitalized patients with influenza A(H1N1)pdm09 also had a higher risk for intensive care unit admission, death, or both than patients with influenza A(H3N2) or B, independent of other factors. Determining the patterns of influenza-associated severity and how they might differ by virus type and subtype can help guide planning and implementation of adequate control and preventive measures during influenza epidemics.engVoRhttp://creativecommons.org/licenses/by-nc-sa/4.0/SpainInfluenza A(H1N1)pdm09Influenza A(H3N2)Influenza BInfluenza hospitalizationsRespiratory infectionsSevere influenzaSurveillanceViral subtypesViral typesVirusesInfluenzaHospitalizationAdolescentAdultAge FactorsAgedAtribución-NoComercial-CompartirIgual 4.0 Internacional31961295262220-22810.3201/eid2602.1817321080-6059Emerging Infectious Diseasesopen access