Resino, SalvadorNavarrete-Muñoz, María ABlanco, JuliàPacheco, Yolanda MaríaCastro, IvánBerenguer, JuanSantos, JesúsVera-Méndez, Francisco JGórgolas, MiguelJimenez-Sousa, Maria AngelesBenito, José MiguelRallón, Norma2020-02-102020-02-102019Biomolecules. 2019 Jun 16;9(6). pii: E233.2218-273Xhttp://hdl.handle.net/10668/14132http://hdl.handle.net/20.500.13003/16530http://hdl.handle.net/20.500.12105/9068Interleukin-7 receptor subunit alpha (IL7RA) rs6897932 polymorphism is related to CD4+ recovery after combination antiretroviral therapy (cART), but no studies so far have analyzed its potential impact in patients with very low CD4+ T-cells count. We aimed to analyze the association between IL7RA rs6897932 polymorphism and CD4+ T-cells count restoration in HIV-infected patients starting combination antiretroviral therapy (cART) with CD4+ T-cells count <200 cells/mm3. We performed a retrospective study in 411 patients followed for 24 months with a DNA sample available for genotyping. The change in CD4+ T-cells count during the follow-up was considered as the primary outcome. The rs6897932 polymorphism had a minimum allele frequency (MAF) >20% and was in Hardy-Weinberg equilibrium (p = 0.550). Of 411 patients, 256 carried the CC genotype, while 155 had the CT/TT genotype. The CT/TT genotype was associated with a higher slope of CD4+ T-cells recovery (arithmetic mean ratio; AMR = 1.16; p = 0.016), higher CD4+ T-cells increase (AMR = 1.19; p = 0.004), and higher CD4+ T-cells count at the end of follow-up (AMR = 1.13; p = 0.006). Besides, rs6897932 CT/TT was related to a higher odds of having a value of CD4+ T-cells at the end of follow-up ≥500 CD4+ cells/mm3 (OR = 2.44; p = 0.006). After multiple testing correction (Benjamini-Hochberg), only the increase of ≥ 400 CD4+ cells/mm3 lost statistical significance (p = 0.052). IL7RA rs6897932 CT/TT genotype was related to a better CD4+ T-cells recovery and it could be used to improve the management of HIV-infected patients starting cART with CD4+ T-cells count <200 cells/mm3.engVoRhttp://creativecommons.org/licenses/by/4.0/CD4HIVIL7RASNPscARTImmune reconstitutionCD4 Lymphocyte CountGenotypeHIV InfectionsMaleReceptors, Interleukin-7AdultFemaleAnti-Retroviral AgentsHumansDrug InteractionsMiddle AgedPolymorphism, Single NucleotideAtribución 4.0 Internacional312081539623310.3390/biom90602332218-273XBiomoleculesopen accessHumanosPersona de Mediana EdadPolimorfismo de Nucleótido SimpleAntirretroviralesInteracciones FarmacológicasGenotipoRecuento de Linfocito CD4FemeninoInfecciones por VIHReceptores de Interleucina-7AdultoMasculino2-s2.0-85068400109475301500029L2002299457