Díaz-López, AndrésPaz-Graniel, IndiraRuiz, VerónicaToledo, EstefaníaBecerra-Tomás, NereaCorella, DoloresCastañer, OlgaMartínez, J AlfredoAlonso-Gómez, Ángel MWärnberg, JuliaVioque, JesúsRomaguera, DoraLópez-Miranda, JoséEstruch, RamonTinahones, Francisco JLapetra, JoséSerra-Majem, LuísBueno-Cavanillas, AuroraTur, Josep ASánchez, Vicente MartínPintó, XavierDelgado-Rodríguez, MiguelMatía-Martín, PilarVidal, JosepVázquez, ClotildeDaimiel, LidiaVilla, Tania FernandezRos, EmilioEguaras, SoniaBabio, NancySorlí, Jose VGoday, AlbertAbete, ItziarSierra, Lucas TojalBarón-López, Francisco JavierTorres-Collado, LauraMorey, MargaGarcia-Rios, AntonioCasas, RosaBernal-López, María RosaSantos-Lozano, José ManuelNavarro, AdelaGonzalez, Jose IZomeño, María DoloresZulet, Maria AngelesLuna, Jessica VaqueroRamallal, RaulFitó, MontseSalas-Salvadó, Jordi2024-02-192024-02-192021-04-22Diaz-Lopez A, Paz-Graniel I, Ruiz V, Toledo E, Becerra-Tomas N, Corella D, et al. Consumption of caffeinated beverages and kidney function decline in an elderly Mediterranean population with metabolic syndrome. Sci Rep. 2021 Apr 22;11(1):8719.http://hdl.handle.net/10668/17621https://hdl.handle.net/20.500.13003/19512http://hdl.handle.net/20.500.12105/18318It remains unclear whether caffeinated beverages could have deleterious renal effects in elderly population with underlying comorbid conditions. We investigated the associations between coffee, tea, or caffeine intake and 1-year changes in glomerular filtration rate (eGFR) in a large Spanish cohort of overweight/obese elderly with metabolic syndrome (MetS). This prospective analysis includes 5851 overweight/obese adults (55-75 years) with MetS from the PREDIMED-Plus study. We assessed coffee, tea, and caffeine consumption from a validated food-frequency questionnaire and creatinine-based eGFR using the Chronic Kidney Disease Epidemiology Collaboration equation. Multivariate-adjusted regression models were applied to test associations between baseline coffee, tea, or caffeine intake and 1-year eGFR changes. Caffeinated coffee (> 2 cups/day) and tea (at least 1 cup/day) drinkers had 0.88 and 0.93 mL/min/1.73 m2 greater eGFR decrease respectively, compared to those with less than 1 cup/day of coffee consumption or non-tea drinkers. Furthermore, caffeinated coffee consumption of > 2 cups/day was associated with 1.19-fold increased risk of rapid eGFR decline > 3 mL/min/1.73 m2 (95% CI 1.01-1.41). Similarly, individuals in the highest (median, 51.2 mg/day) tertile of caffeine intake had a 0.87 mL/min/1.73 m2 greater eGFR decrease. Decaffeinated coffee was not associated with eGFR changes. In conclusion, higher consumption of caffeinated coffee, tea, and caffeine was associated with a greater 1-year eGFR decline in overweight/obese adults with MetS.engVoRhttp://creativecommons.org/licenses/by/4.0/AgedCaffeineCoffeeCohort StudiesDrinking BehaviorFemaleGlomerular Filtration RateHumansKidneyMaleMetabolic SyndromeMiddle AgedSpainTeaAttribution 4.0 International33888780111871910.1038/s41598-021-88028-72045-2322Scientific reportsopen accessEstudios de CohortesTéSíndrome MetabólicoFemeninoMasculinoCafeínaRiñónCaféConducta de Ingestión de LíquidoHumanosPersona de Mediana EdadAncianoTasa de Filtración GlomerularEspaña2-s2.0-85104626272642742500072L634870788