Garcia-Alvarez, MonicaBerenguer, JuanGuzman-Fulgencio, MariaAlvarez, EmilioCosín, JaimeMicheloud, DarielaJimenez-Sousa, Maria AngelesFernandez-Rodriguez, AmandaAldámiz-Echevarría, TeresaCarrero, AnaMiralles, PilarResino, Salvador2024-02-032024-02-032012-12-15J Acquir Immune Defic Syndr. 2012 Dec 15;61(5):552-6.http://hdl.handle.net/20.500.12105/17445We carried out a cross-sectional study to explore whether bacterial 16S ribosomal DNA (bactDNA) shows association with severity of liver disease among human immunodeficiency virus/hepatitis C virus coinfected patients. Patients with advanced fibrosis (F3/F4), moderate activity grade (A2/A3), and high fibrosis progression rate (FPR > 0.15) had higher values of plasma bactDNA levels than did patients without these markers of liver disease (P < 0.05). The chance of having a fibrosis stage or activity grade increased was 1.20 [95% confidence interval (CI) = 1.0 to 1.44, P = 0.045] and 1.22 (95% CI = 1.1 to 1.45, P = 0.029) times greater for every 100 copies per microliter of plasma bactDNA. Likewise, the odds of having values of FPR > 0.15 was 1.18 (95% CI = 0.98 to 1.42, P = 0.089). In addition, patients with high bactDNA levels (≥175 copies per microliter) had the highest odds of having high values of Metavir score and FPR (P < 0.05). Our data show that bacterial translocation is associated with severe liver disease among human immunodeficiency virus-infected patients with chronic hepatitis C.engAM16S rDNABacterial translocationHepatitis CHIV/ AIDSLiver biopsyAdultBase SequenceBiological Transport, ActiveCross-Sectional StudiesDNA, BacterialDisease ProgressionFemaleHIV InfectionsHepatitis C, ChronicHumansIntestinal MucosaLiver CirrhosisMaleRNA, Ribosomal, 16SAttribution-NonCommercial-NoDerivatives 4.0 Internacional22932319615552-55610.1097/QAI.0b013e31826ea1091944-7884Journal of acquired immune deficiency syndromes (1999)open access