Pernas, MariaSanchez-Merino, VictorCasado, ConcepcionMerino-Mansilla, AlbertoOlivares, IsabelYuste-Herranz, Maria EloisaLopez-Galindez, Luis Cecilio2018-12-212018-12-212015-08-10PLoS One. 2015 Aug 10;10(8):e01340541932-6203http://hdl.handle.net/20.500.12105/6929This study evaluated the neutralization breadth in dually infected (DI) HIV-1 long-term non-progressor elite controller patients (LTNP-EC) using a representative minipanel of 6 viruses from 5 different subtypes. Our results showed an improved neutralization breadth in DI LTNP-EC patients when compared with matched LTNP single-infected patients. The role of viral diversity in neutralization was estimated with the Shannon Entropy and the p-distance in viral quasispecies. We found a positive correlation between neutralization breadth and diversity within the viral quasispecies. This correlation could explain why a group of LTNP-EC patients developed a broad neutralizing response despite having undetectable levels of viremia.engVoRhttp://creativecommons.org/licenses/by/4.0/Antibodies, NeutralizingEntropyFollow-Up StudiesGenetic VariationHIV AntibodiesHIV InfectionsHIV-1HumansNeutralization TestsPhylogenyViral LoadViremiaHIV Long-Term SurvivorsAtribución 4.0 Internacional26258485108e013405410.1371/journal.pone.01340541932-6203PloS oneopen access