A human genome editing-based MLL::AF4 ALL model recapitulates key cellular and molecular leukemogenic features.

Bueno, ClaraTorres-Ruiz, RaulVelasco-Hernandez, TaliaMolina, OscarPetazzi, PaoloMartinez, AlbaRodriguez, VirginiaVinyoles, MeritxellCantilena, SandraWilliams, OwenVega-Garcia, NereaRodriguez Perales, SandraSegovia, Jose CQuintana-Bustamante, OscarRoy, AninditaMeyer, ClausMarschalek, RolfSmith, Alastair LMilne, Thomas AFraga, Mario FTejedor, Juan RamónMenéndez, Pablo2025-01-272025-01-272023-11-16Blood . 2023 Nov 16;142(20):1752-1756.https://hdl.handle.net/20.500.12105/26144Cellular ontogeny and MLL breakpoint site influence the capacity of MLL-edited CD34+ hematopoietic cells to initiate and recapitulate infant patients' features in pro-B-cell acute lymphoblastic leukemia (B-ALL). We provide key insights into the leukemogenic determinants of MLL-AF4+ infant B-ALL.engVoRhttp://creativecommons.org/licenses/by-nc-nd/4.0/ACUTE LEUKEMIASRECOMBINOMEBREAKPOINTSBIOLOGYMLL-AF4A human genome editing-based MLL::AF4 ALL model recapitulates key cellular and molecular leukemogenic features.Attribution-NonCommercial-NoDerivatives 4.0 International37756522142201752-1756Bloodopen access