Diaz-Cordovés Rego, GiselaNúñez-Cuadros, EsmeraldaMena-Vázquez, NataliaAguado Henche, SoledadGalindo-Zavala, RocíoManrique-Arija, SaraMartín-Pedraz, LauraRedondo-Rodríguez, RocioGodoy-Navarrete, Francisco JavierFernández-Nebro, Antonio2024-02-192024-02-192021-08-31http://hdl.handle.net/10668/4274http://hdl.handle.net/20.500.12105/18452Objective: To identify factors associated with the higher proportion of fatty tissue and overweight/obesity observed in patients with juvenile idiopathic arthritis (JIA). Patients and methods: We performed a cross-sectional study of 80 JIA patients aged 4–15 years with 80 age- and sex-matched healthy controls. Body composition was assessed using dual-energy x-ray absorptiometry. The 27-joint Juvenile Arthritis Disease Activity score (JADAS27) was calculated. Two multivariate models were constructed to identify factors associated with overweight/obesity and fat mass index (FMI). Results: No differences were found between cases and controls in body mass index (BMI) or body composition. However, compared with controls, patients with a high inflammatory activity (JADAS27 > 4.2 for oligoarticular JIA or >8.5 for polyarticular disease) had higher values for BMI (p = 0.006); total fat mass (p = 0.003); FMI (p = 0.001); and fat in the legs (p = 0.001), trunk (p = 0.001), and arms (p = 0.002). The factors associated with overweight/obesity in patients were the duration of therapy with biological drugs, measured in months (OR [95% CI] = 1.12 [1.02–1.04]; p = 0.037), and physical activity (OR [95% CI] = 0.214 [0.07–0.68]; p = 0.010), while the factors associated with FMI were age (β [95% CI] = 0.30 [0.17–1.41]; p = 0.014), JADAS27 (β [95% CI] = 0.45 [0.16–1.08]; p = 0.009), and physical activity (β [95% CI] = −0.22 [−5.76 to 0.29]; p = 0.031). Conclusion: Our study revealed no differences between JIA patients with well-controlled disease and low disability and the healthy population in BMI or body composition. Furthermore, the association observed between inflammatory activity and adiposity could be responsible for poorer clinical course.engVoRhttp://creativecommons.org/licenses/by/4.0/Juvenile idiopathic arthritisAdiposityInflammatory disease activityBody mass indexDual-energy x-ray absorptiometryOverweightObesityBody compositionArtritis juvenilAdiposidadÍndice de masa corporalAbsorciometría de fotónSobrepesoObesidadComposición corporalHumansBody Mass IndexAbsorptiometry, PhotonOverweightAdiposityCross-Sectional StudiesArthritis, JuvenileLegBody CompositionObesityAdipose TissueBiological ProductsExerciseAttribution 4.0 International3450139610.3390/jcm101739492077-0383Journal of Clinical Medicineopen access