Rodríguez-Capitán, JorgeSánchez-Pérez, AndrésBallesteros-Pradas, SaraMillán-Gómez, MercedesCardenal-Piris, RosaOneto-Fernández, ManuelGutiérrez-Alonso, LolaRivera-López, RicardoGuisado-Rasco, AgustínCano-García, MacarenaGutiérrez-Bedmar, MarioJiménez-Navarro, Manuel2024-02-192024-02-192021-04-252077-0383http://hdl.handle.net/10668/17704http://hdl.handle.net/20.500.12105/18322The clinical significance of non-obstructive coronary artery disease is the subject of debate. Our objective was to evaluate the long-term cardiovascular prognosis associated with non-obstructive coronary artery disease in patients undergoing coronary angiography, and to conduct a stratification by sex, diabetes, and clinical indication. We designed a multi-centre retrospective longitudinal observational study of 3265 patients that were classified into three groups: normal coronary arteries (lesion 70%, 1196 patients). During a mean follow-up of 43 months, we evaluated a combined cardiovascular event: acute myocardial infarction, stroke, hospitalization for heart failure, or cardiovascular death. Multivariable-adjusted Cox proportional hazard models showed a worse prognosis in patients with non-obstructive coronary artery disease, in comparison with patients of normal coronary arteries group, in the total population (hazard ratio 1.72, 95% confidence interval 1.23-2.39; p for trendengVoRhttp://creativecommons.org/licenses/by/4.0/acute coronary syndromecoronary angiographycoronary artery diseasediabetes mellitussexAttribution 4.0 International3392311010910.3390/jcm10091863Journal of clinical medicineopen access