Sánchez-Álvarez, Migueldel Pozo, Miguel Angel2023-11-282023-11-282022-05-02J Cell Biol. 2022 May 2;221(5):e202203137.http://hdl.handle.net/20.500.12105/16740Programmed cell death-ligand 1 (PD-L1)-mediated T cell inhibition through PD-1 is a key checkpoint frequently exploited by tumors to evade immunity. In this issue, Wang et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202108083) reveal an unexpected role for PD-L1 in promoting tumor cell front-rear polarity and directionally persistent cell migration, independently of PD-1.engVoRB7-H1 AntigenNeoplasmsCell MovementHumansProgrammed Cell Death 1 ReceptorT-LymphocytesTumor EscapeAttribution-NonCommercial-NoDerivatives 4.0 Internacional35416931221510.1083/jcb.2022031371540-8140The Journal of cell biologyopen access