Oteo-Iglesias, JesusLázaro, EdurneAbajo Iglesias, Francisco J deBaquero, FernandoCampos, Jose2020-05-052020-05-052005-04Emerg Infect Dis. 2005 Apr;11(4):546-53.1080-6040http://hdl.handle.net/20.500.12105/9885Surveillance System. A network of 32 Spanish hospitals, serving approximately 9.6 million persons, submitted antimicrobial-susceptibility data on 7,098 invasive Escherichia coli species (2001-2003). Resistance to ampicillin, cotrimoxazole, ciprofloxacin, gentamicin, and tobramycin was found at rates of 59.9%, 32.6%, 19.3%, 6.8%, and 5.3%, respectively. Resistance to multiple drugs increased from 13.8% in 2001 to 20.6% in 2003 (p <0.0001). Antimicrobial consumption data were obtained from the Spanish National Health System. In spite of decreased cephalosporin and beta-lactam use, overall extended-spectrum beta-lactamase production increased from 1.6% (2001) to 4.1% (2003) (p <0.0001), mainly due to the rising prevalence of cefotaximases. Resistance to ciprofloxacin significantly increased, mostly in community-onset infections, which coincided with a rise in community quinolone use. Cotrimoxazole resistance remained stable at approximately 30%, even though its use was dramatically reduced.engVoRhttp://creativecommons.org/licenses/by-nc-sa/4.0/Anti-Bacterial AgentsDrug Resistance, Multiple, BacterialEscherichia coliEscherichia coli InfectionsHumansProspective StudiesSpainTime FactorsDrug Resistance, BacterialAtribución-NoComercial-CompartirIgual 4.0 Internacional15829192114546-5310.3201/eid1104.040699Emerging infectious diseasesopen access