Barceló Bennasar, AntoniaEsquinas, CristinaRobles, JuanPierola Lopetegui, Javierde la Pena-Bravo, MonicaAguilar, IreneMorell Garcia, DanieAlonso, AlbertoToledo Pons, NuriaSanchez-de la Torre, ManuelBarbe, Ferran2024-07-092024-07-092016-10Barcelo Bennasar Antonia, Esquinas Cristina, Robles Juan, Pierola Javier, De La Peña Bravo Mónica, Aguilar Irene, et al. Gut epithelial barrier markers in patients with obstructive sleep apnea. Sleep Med. 2016 Oct;26:12-15. Epub 2016 Sep 28.1389-9457http://hdl.handle.net/20.500.13003/10169http://hdl.handle.net/20.500.12105/20314Background: Obstructive sleep apnea (OSA) is now being recognized as an additional contributing factor to the pathogenesis of obesity-related comorbidities. At the same time, there is now increasing evidence to suggest that intestinal wall permeability plays a role in the development of metabolic syndrome. In the present study, circulating zonulin and fatty acid binding protein (I-FABP) were measured in association with metabolic, hepatic, and inflammatory parameters. Results: Compared with controls, plasma I-FABP levels were significantly higher in patients with OSA (571 pg/mL [IQR 290-950] vs 396 pg/mL [IQR 234-559], p = 0.04). Zonulin levels were similar between groups. Significant relationships were observed between zonulin levels and waist circumference (p < 0.05), glucose (p < 0.05), and insulin (p < 0.05). In addition, in the OSA group, zonulin levels correlated negatively with the mean nocturnal oxygenation saturation (p < 0.05) and positively with total cholesterol (p < 0.05), alanine aminotransferase (ALT) (p < 0.005), aminotransferase (AST) (p < 0.01), gamma glutamyltransferase (GGT) (p < 0.005), and high-sensitivity C-reactive protein (hs-CRP) (p < 0.05). Multivariate analysis showed that associations between zonulin and ALT, AST, and hs-CRP were attenuated, but not eliminated, after adjustment for other variables. Conclusions: The results of this study suggest that OSA is a risk factor for intestinal damage, regardless of metabolic profile, and that intestinal permeability might be a possible contributor to nonalcoholic fatty liver disease in patients with OSA.engSMURhttps://creativecommons.org/licenses/by-nc-nd/4.0/ZonulinFatty acid binding protein (I-FABP)Intestinal wallSleep apneaMetabolic SyndromeCase-Control StudiesAdultIntestinal AbsorptionSleep Apnea, ObstructiveCholera ToxinHumansAlanine TransaminaseIntestinal MucosaMiddle AgedNon-alcoholic Fatty Liver DiseaseObesityMaleBiomarkersFemaleFatty Acid-Binding ProteinsWaist CircumferenceRetrospective StudiesAttribution-NonCommercial-NoDerivatives 4.0 International280073542601/12/1510.1016/j.sleep.2016.01.0191878-5506Sleep Medicineopen accessBiomarcadoresSíndrome MetabólicoFemeninoEnfermedad del Hígado Graso no AlcohólicoMasculinoCircunferencia de la CinturaToxina del CóleraApnea Obstructiva del SueñoHumanosPersona de Mediana EdadObesidadAlanina TransaminasaMucosa IntestinalProteínas de Unión a ácidos GrasosEstudios RetrospectivosAdultoAbsorción IntestinalEstudios de Casos y Controles2-s2.0-84992740414390720900003L612928380