Ballesteros Vizoso, AntonietaFigueras-Castilla, AlbertBarceló Bennasar, AntoniaRaurich, Joan MariaArgente del Castillo, PaulaMorell Garcia, DanielVelasco, JulioPérez-Bárcena, JonLlompart-Pou, Juan Antonio2024-09-182024-09-182021-10-29Ballesteros Vizoso MA, Castilla AF, Barceló A, Raurich JM, Argente del Castillo P, Morell-García D, et al. Thyroid Disfunction in Critically Ill COVID-19 Patients. Relationship with In-Hospital Mortality. J Clin Med. 2021;10(21):5057.2077-0383http://hdl.handle.net/20.500.13003/18647https://hdl.handle.net/20.500.12105/23311The incidence of thyroid disfunction has not been analyzed in critically ill COVID-19 patients. Our objective was to analyze the relationship of the thyroid profile and in-hospital mortality in critically ill COVID-19 patients. This was a prospective single-center study involving critically ill COVID-19 patients admitted to the ICU of a tertiary University Hospital. Thyroid hormones were measured through drawing blood samples from a central venous catheter at ICU admission and on the fifth day. A multiple logistic regression analysis was performed to analyze the variables associated with mortality. The ability of the different thyroid hormones to predict in-hospital mortality was evaluated by calculating the receiver operating characteristics (ROCs) and the area under the curve (AUC). A total of 78 patients were included in the study at ICU admission; 72 had their thyroid profile measured at day 5. In-hospital mortality reached 29.5%. Multiple logistic regression analysis showed that variables associated with mortality were age and prior beta-blocker therapy at ICU admission and age fT4 at day 5. The AUC for in-hospital mortality predictions of fT4 at day 5 was 0.69. Thyroid responses are commonly observed in critically ill COVID-19 patients. fT4 at day 5 after ICU admission was associated with mortality.enghttp://creativecommons.org/licenses/by/4.0/research articleAttribution 4.0 International34768580102110.3390/jcm10215057Journal of clinical medicineopen access2-s2.0-85118122339718840400001L2014311031