Type 2 diabetes and cognitive impairment in an older population with overweight or obesity and metabolic syndrome: baseline cross-sectional analysis of the PREDIMED-plus study.

Mallorquí-Bagué, NúriaLozano-Madrid, MaríaToledo, EstefaníaCorella, DoloresSalas-Salvadó, JordiCuenca-Royo, AidaVioque, JesúsRomaguera, DoraMartínez, J AlfredoWärnberg, JuliaLópez-Miranda, JoséEstruch, RamónBueno-Cavanillas, AuroraAlonso-Gómez, ÁngelTur, Josep ATinahones, Francisco JSerra-Majem, LluísMartín, VicenteLapetra, JoséVázquez, ClotildePintó, XavierVidal, JosepDaimiel, LidiaGaforio, José JMatía, PilarRos, EmilioGranero, RoserBuil-Cosiales, PilarBarragán, RocíoBulló, MònicaCastañer, OlgaGarcía-de-la-Hera, ManoliYáñez, Aina MAbete, ItziarGarcía-Ríos, AntonioRuiz-Canela, MiguelDíaz-López, AndrésJiménez-Murcia, SusanaMartínez-González, Miguel ADe la Torre, RafaelFernández-Aranda, Fernando2024-02-082024-02-082018-10-31http://hdl.handle.net/10668/13146http://hdl.handle.net/20.500.13003/9064http://hdl.handle.net/20.500.12105/17637This study cross-sectionally examines in the elderly population: (a) the association of type 2 diabetes with executive function (EF); (b) the effect of BMI on both type 2 diabetes and EF; (c) the association between glycaemia control and EF in type 2 diabetes. 6823 older individuals with overweight/obesity and metabolic syndrome participating in the PREDIMED-PLUS study, were assessed with a battery of cognitive tests and a medical interview. ANOVA showed a significantly worse performance on EF in type 2 diabetes vs. non-diabetic individuals. Two complementary models were displayed: (1) in the whole sample, the presence of type 2 diabetes, depressive symptoms and BMI had a direct negative effect on EF, while apnoea had an indirect negative effect; (2) in the diabetes subsample, higher illness duration was associated with worse performance in EF. Participants with type 2 diabetes and HbA1cengVoRhttp://creativecommons.org/licenses/by/4.0/AgedBody Mass IndexCognitive DysfunctionCross-Sectional StudiesDiabetes Mellitus, Type 2FemaleGlycated HemoglobinHumansMaleMetabolic SyndromeMiddle AgedObesityType 2 diabetes and cognitive impairment in an older population with overweight or obesity and metabolic syndrome: baseline cross-sectional analysis of the PREDIMED-plus study.Attribution 4.0 International30382190811612810.1038/s41598-018-33843-82045-2322Scientific reportsopen accessÍndice de Masa CorporalDisfunción CognitivaEstudios TransversalesHumanosPersona de Mediana EdadObesidadSíndrome MetabólicoAncianoDiabetes Mellitus Tipo 2FemeninoHemoglobina A GlucadaMasculino2-s2.0-85055818232448814600026L624724993