Escala-Garcia, MariaAbraham, JeanAndrulis, Irene LAnton-Culver, HodaArndt, VolkerAshworth, AlanAuer, Paul LAuvinen, PäiviBeckmann, Matthias WBeesley, JonathanBehrens, SabineBenitez, JavierBermisheva, MarinaBlomqvist, CarlBlot, WilliamBogdanova, Natalia VBojesen, Stig EBolla, Manjeet KBørresen-Dale, Anne-LiseBrauch, HiltrudBrenner, HermannBrucker, Sara YBurwinkel, BarbaraCaldas, CarlosCanzian, FedericoChang-Claude, JennyChanock, Stephen JChin, Suet-FeungClarke, Christine LCouch, Fergus JCox, AngelaCross, Simon SCzene, KamilaDaly, Mary BDennis, JoeDevilee, PeterDunn, Janet ADunning, Alison MDwek, MiriamEarl, Helena MEccles, Diana MEliassen, A HeatherEllberg, CarolinaEvans, D GarethFasching, Peter AFigueroa, JonineFlyger, HenrikGago-Dominguez, ManuelaGapstur, Susan MGarcía-Closas, MontserratGarcía-Sáenz, José AGaudet, Mia MGeorge, AngelaGiles, Graham GGoldgar, David EGonzález-Neira, AnnaGrip, MerviGuénel, PascalGuo, QiHaiman, Christopher AHåkansson, NiclasHamann, UteHarrington, Patricia AHiller, LouiseHooning, Maartje JHopper, John LHowell, AnthonyHuang, Chiun-ShengHuang, GuanmengqianHunter, David JJakubowska, AnnaJohn, Esther MKaaks, RudolfKapoor, Pooja MiddhaKeeman, RenskeKitahara, Cari MKraft, PeterLambrechts, DietherLe Marchand, LoicLejbkowicz, FlavioLindblom, AnnikaLubiński, JanMannermaa, ArtoManoochehri, MehdiManoukian, SiranoushMargolin, SaraMartinez, Maria ElenaMaurer, TabeaMavroudis, DimitriosMeindl, AlfonsMilne, Roger LMulligan, Anna MarieNeuhausen, Susan LNevanlinna, HeliNewman, William GOlshan, Andrew FOlson, Janet EOlsson, HåkanOrr, NickPeterlongo, PaoloPetridis, ChristosPrentice, Ross LPresneau, NadegePunie, KevinRamachandran, DhanyaRennert, GadRomero, AtochaSachchithananthan, MythilySaloustros, EmmanouilSawyer, Elinor JSchmutzler, Rita KSchwentner, LukasScott, ChristopherSimard, JacquesSohn, ChristofSouthey, Melissa CSwerdlow, Anthony JTamimi, Rulla MTapper, William JTeixeira, Manuel RTerry, Mary BethThorne, HeatherTollenaar, Rob A E MTomlinson, IanTroester, Melissa ATruong, ThérèseTurnbull, ClareVachon, Celine Mvan der Kolk, Lizet EWang, QinWinqvist, RobertWolk, AlicjaYang, Xiaohong RZiogas, ArgyriosPharoah, Paul D PHall, PerWessels, Lodewyk F AChenevix-Trench, GeorgiaBader, Gary DDörk, ThiloEaston, Douglas FCanisius, SanderSchmidt, Marjanka KGonzalez Neira, AnnaAndrulis, Irene L.Auer, Paul L.Beckmann, Matthias W.Bogdanova, Natalia V.Bojesen, Stig E.Bolla, Manjeet K.Brucker, Sara Y.Chanock, Stephen J.Clarke, Christine L.Couch, Fergus J.Cross, Simon S.Daly, Mary B.Dunn, Janet A.Dunning, Alison M.Earl, Helena M.Eccles, Diana M.Eliassen, A. HeatherEvans, D. GarethFasching, Peter A.Gapstur, Susan M.García-Sáenz, José A.Gaudet, Mia M.Giles, Graham G.Goldgar, David E.Haiman, Christopher A.Harrington, Patricia A.Hooning, Maartje J.Hopper, John L.Hunter, David J.John, Esther M.Kitahara, Cari M.Koppert, Linetta BKristensen, Vessela NMilne, Roger L.Neuhausen, Susan L.Newman, William G.Olshan, Andrew F.Olson, Janet E.Prentice, Ross L.Sawyer, Elinor J.Schmutzler, Rita K.Southey, Melissa C.Swerdlow, Anthony J.Tamimi, Rulla M.Tapper, William J.Tollenaar, Rob A. E. M.Troester, Melissa A.Vachon, Celine M.van der Kolk, Lizet E.Yang, Xiaohong R.Pharoah, Paul D. P.Wessels, Lodewyk F. A.Bader, Gary D.Easton, Douglas F.Schmidt, Marjanka K.2021-03-102021-03-102020-11-01Nat Commun.2020 ;11(1):312http://hdl.handle.net/20.500.12105/12181Identifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-based approach to handle underpowered complex datasets to provide new insights into the potential function of germline variants in breast cancer prognosis. This network-based analysis studies ~7.3 million variants in 84,457 breast cancer patients in relation to breast cancer survival and confirms the results on 12,381 independent patients. Aggregating the prognostic effects of genetic variants across multiple genes, we identify four gene modules associated with survival in estrogen receptor (ER)-negative and one in ER-positive disease. The modules show biological enrichment for cancer-related processes such as G-alpha signaling, circadian clock, angiogenesis, and Rho-GTPases in apoptosis.engVoRhttp://creativecommons.org/licenses/by-nc-sa/4.0/Genetic VariationGenome-Wide Association StudyGerm CellsApoptosisBreast NeoplasmsCircadian ClocksComputational BiologyFemaleGTP-Binding Protein alpha SubunitsGTP-Binding Protein alpha Subunits, Gq-G11Gene Regulatory NetworksGenotypeHumansPrognosisReceptors, EstrogenSignal TransductionAtribución-NoComercial-CompartirIgual 4.0 Internacional3194916111131210.1038/s41467-019-14100-62041-1723Nature communicationsopen access