Serrano Pariente, JoséPlaza, VSoriano, Joan BMayos, MLopez-Vina, APicado, CVigil, LCPASMA Trial Grp2024-07-112024-07-112017-05Serrano-Pariente J, Plaza V, Soriano JB, Mayos M, Lopez-Vina A, Picado C, et al. Asthma outcomes improve with continuous positive airway pressure for obstructive sleep apnea. Allergy. 2017 May;72(5):802-12. Epub 2016 Nov 3.0105-4538http://hdl.handle.net/20.500.13003/17172http://hdl.handle.net/20.500.12105/20379BackgroundContinuous positive airway pressure (CPAP) in asthma patients with concomitant obstructive sleep apnea syndrome (OSAS) seems to have a favorable impact on asthma, but data are inconsistent due to methodological limitations of previous studies. MethodsProspective, multicenter study. We examined asthma outcomes after 6 months of CPAP in 99 adult asthma patients (mean age 57 years) with OSAS (respiratory disturbance index 20). Asthma control and quality of life were assessed with the Asthma Control Questionnaire (ACQ) and the Mini Asthma Quality of Life Questionnaire (MiniAQLQ), respectively. Data were analyzed by intention-to-treat basis. ResultsThe mean SD score of the ACQ decreased from 1.39 +/- 0.91 at baseline to 1.0 +/- 0.78 at 6 months (P = 0.003), the percentage of patients with uncontrolled asthma from 41.4% to 17.2% (P = 0.006), and the percentage of patients with asthma attacks in the 6 months before and after treatment from 35.4% to 17.2% (P = 0.015). The score of the mAQLQ increased from 5.12 +/- 1.38 to 5.63 +/- 1.17 (P = 0.009). There were also significant improvements in symptoms of gastroesophageal reflux and rhinitis, bronchial reversibility, and exhaled nitric oxide values (all P < 0.05). No significant changes were observed in drug therapy for asthma or their comorbidities nor in the patients' weight. ConclusionsAsthma control (both actual and future risk), quality of life, and lung function improved after starting continuous positive airway pressure in asthmatics with moderate to severe obstructive sleep apnea syndrome.enghttp://creativecommons.org/licenses/by-nc-nd/4.0/AsthmaBronchial hyperreactivityContinuous positive airway pressureObstructive sleep apnea syndromeQuality of lifeAsthmaContinuous Positive Airway PressureDisease ProgressionAgedAdultSleep Apnea, ObstructiveHumansMiddle AgedPatient Outcome AssessmentRespiratory Function TestsMaleQuality of LifeSeverity of Illness IndexProspective StudiesFemaleRisk FactorsTreatment Outcomeresearch articleAttribution-NonCommercial-NoDerivatives 4.0 International27732758725802-81210.1111/all.130701398-9995Allergyopen accessResultado del TratamientoFemeninoPresión de las Vías Aéreas Positiva ContínuaMasculinoApnea Obstructiva del SueñoFactores de RiesgoHumanosPersona de Mediana EdadCalidad de VidaPruebas de Función RespiratoriaEvaluación del Resultado de la Atención al PacienteEstudios ProspectivosAncianoAsmaÍndice de Severidad de la EnfermedadProgresión de la EnfermedadAdulto2-s2.0-84996836542398734600014L613410808