Olmedo, Dionisio ALópez-Pérez, José LuisDel Olmo, EstherBedoya, Luis MSancho, RocíoAlcamí, JoséMuñoz, EduardoFeliciano, Arturo SanGupta, Mahabir P2019-02-192019-02-192017-02-19Molecules. 2017 Feb 19;22(2). pii: E321.1420-3049http://hdl.handle.net/20.500.12105/7183Twenty-eight neoflavonoids have been prepared and evaluated in vitro against HIV-1. Antiviral activity was assessed on MT-2 cells infected with viral clones carrying the luciferase reporter gene. Inhibition of HIV transcription and Tat function were tested on cells stably transfected with the HIV-LTR and Tat protein. Seven 4-phenylchromen-2-one derivatives showed HIV transcriptional inhibitory activity but only the phenylchrome-2-one 10 inhibited NF-κB and displayed anti-Tat activity simultaneously. Compounds 10, 14, and 25, inhibited HIV replication in both targets at concentrations <25 μM. The assays of these synthetic 4-phenylchromen-2-ones may aid in the investigation of some aspects of the anti-HIV activity of such compounds and could serve as a scaffold for designing better anti-HIV compounds, which may lead to a potential anti-HIV therapeutic drug.engVoRhttp://creativecommons.org/licenses/by/4.0/4-phenyl-chromen-oneAIDSNF-κB inhibitionTat proteinAnti-HIV activityNeoflavonoidsAnti-HIV AgentsBiflavonoidsHIV InfectionsHIV-1HumansMicrobial Sensitivity TestsMolecular StructureNF-kappa BSignal TransductionVirus Replicationtat Gene Products, Human Immunodeficiency VirusAtribución-4.0 Internacional2821873022232110.3390/molecules22020321Molecules (Basel, Switzerland)open access