García-Casares, NataliaBernal-López, María RRoé-Vellvé, NuriaGutiérrez-Bedmar, MarioFernández-García, José CarlosGarcía-Arnés, Juan ARamos-Rodriguez, José RAlfaro, FranciscoSantamaria-Fernández, SoniaSteward, TrevorJiménez-Murcia, SusanaGarcia-Garcia, IsabelValdivielso, PedroFernández-Aranda, FernandoTinahones, Francisco JGómez-Huelgas, Ricardo2024-01-232024-01-232017-07-01http://hdl.handle.net/10668/11367http://hdl.handle.net/20.500.12105/17324Functional magnetic resonance imaging (fMRI) in the resting state has shown altered brain connectivity networks in obese individuals. However, the impact of a Mediterranean diet on cerebral connectivity in obese patients when losing weight has not been previously explored. The aim of this study was to examine the connectivity between brain structures before and six months after following a hypocaloric Mediterranean diet and physical activity program in a group of sixteen obese women aged 46.31 ± 4.07 years. Before and after the intervention program, the body mass index (BMI) (kg/m²) was 38.15 ± 4.7 vs. 34.18 ± 4.5 (pengVoRhttp://creativecommons.org/licenses/by/4.0/Mediterranean dietconnectivityfunctional MRIinferior parietal lobeinsulaobesityphysical activityposterior cingulateprefrontal cortexresting statesomatosensory cortextemporal lobeAdultCaloric RestrictionCerebral CortexDiet, MediterraneanExerciseFemaleHumansMiddle AgedObesityAttribution 4.0 International286715589710.3390/nu90706852072-6643Nutrientsopen access