Gironès, NúriaCarrasco-Marin, EugenioCuervo, HenarGuerrero, Néstor AdriánSanoja, CristinaJohn, SparrowFlores-Herráez, ReyesFernández-Prieto, LorenaChico-Calero, IsabelSalgado, HugoCarrión, JavierFresno, Manuel2024-02-012024-02-012007-06Ann N Y Acad Sci. 2007 Jun:1107:434-44.0077-8923http://hdl.handle.net/20.500.12105/17402Chagas disease, caused by Trypanosoma cruzi, affects several million people in Central and South America. About 30% of chronic patients develop cardiomyopathy probably caused by parasite persistence and/or autoimmunity. While several cross-reactive antibodies generated during mammal T. cruzi infection have been described, very few cross-reactive T cells have been identified. We performed adoptive transfer experiments of T cells isolated from chronically infected mice. The results showed the generation of cardiac pathology in the absence of parasites. We also transferred cross-reactive SAPA-specific T cells and observed unspecific alterations in heart repolarization, cardiac inflammatory infiltration, and tissue damage.engCVoRAnimalsAutoimmunityChagas DiseaseEpitopesHumansMolecular MimicryT-LymphocytesTrypanosoma cruziAttribution-NonCommercial-NoDerivatives 4.0 Internacional17804572110743410.1196/annals.1381.046Annals of the New York Academy of Sciencesopen access