Pascual, SergiFeimer, JanDe Soyza, AnthonyRoig, Jaume SauledaHaughney, JohnPadulles, LauraSeoane, BeatrizRekeda, LudmylaRibera, AnnaChrystyn, Henry2024-07-042024-07-042015-04-30Pascual S, Feimer J, De Soyza A, Sauleda Roig J, Haughney J, Padulles L, et al. Preference, satisfaction and critical errors with Genuair and Breezhaler inhalers in patients with COPD: a randomised, cross-over, multicentre study. NPJ Prim Care Respir Med. 2015 Apr 30;25:15018.2055-1010http://hdl.handle.net/20.500.13003/10874http://hdl.handle.net/20.500.12105/20114BACKGROUND: The specific attributes of inhaler devices can influence patient use, satisfaction and treatment compliance, and may ultimately impact on clinical outcomes in patients with chronic obstructive pulmonary disease (COPD). AIMS: To assess patient preference, satisfaction and critical inhaler technique errors with Genuair (a multidose inhaler) and Breezhaler (a single-dose inhaler) after 2 weeks of daily use. METHODS: Patients with COPD and moderate to severe airflow obstruction were randomised in a cross-over, open-label, multicentre study to consecutive once-daily inhalations of placebo via Genuair and Breezhaler, in addition to current COPD medication. The primary end point was the proportion of patients who preferred Genuair versus Breezhaler after 2 weeks (Patient Satisfaction and Preference Questionnaire). Other end points included overall satisfaction and correct use of the inhalers after 2 weeks, and willingness to continue with each device. RESULTS: Of the 128 patients enrolled, 127 were included in the safety population (male n = 91; mean age 67.6 years). Of the 110 of the 123 patients in the intent-to-treat population who indicated an inhaler preference, statistically significantly more patients preferred Genuair than Breezhaler (72.7 vs. 27.3%; P < 0.001). Mean overall satisfaction scores were also greater for Genuair than for Breezhaler (5.9 vs. 5.3, respectively; P < 0.001). After 2 weeks, there was no statistically significant difference in the number of patients who made >= 1 critical inhaler technique error with Breezhaler than with Genuair (7.3 vs. 3.3%, respectively). CONCLUSIONS: Patient overall preference and satisfaction was significantly higher with Genuair compared with Breezhaler. The proportion of patients making critical inhaler technique errors was low with Genuair and Breezhaler.enghttp://creativecommons.org/licenses/by/4.0/AgedMaleEquipment Designresearch articleAttribution 4.0 International25927321251501810.1038/npjpcrm.2015.18NPJ Primary Care Respiratory Medicineopen accessEnfermedad Pulmonar Obstructiva CrónicaHumanosPersona de Mediana EdadSatisfacción del PacienteAncianoEstudios CruzadosFemeninoDiseño de EquipoFármacos del Sistema RespiratorioFalla de EquipoMasculinoNebulizadores y Vaporizadores2-s2.0-84933535700354189900001L605195736