Andres, PilarVico, HelenaYáñez, Aina MSiquier, AntóniaAmer Ferrer, Guillermo2024-09-102024-09-102019Andres P, Vico H, Yañez A, Siquier A, Amer Ferrer G. Quantifying memory deficits in amnestic mild cognitive impairment.. Alzheimers Dement (Amst). 2019;11:108-114.2352-8729http://hdl.handle.net/20.500.13003/17420https://hdl.handle.net/20.500.12105/22835Introduction: In the present study, we use the item-specific deficit approach (ISDA), a method for characterizing memory deficits in list-learning, to portray the memory deficits in amnestic mild cognitive impairment (aMCI).Methods: We applied the ISDA to compare memory performance of patients with aMCI and healthy controls in encoding, consolidation, and retrieval using the Free and Cued Selective Reminding Test.Results: The results revealed clear differences in recall performance between patients with aMCI and controls. When analyzing the ISDA deficit indices, the results revealed a prominent encoding deficit, followed by a consolidating deficit. A greater sensitivity for the encoding index confirmed that a difficulty with encoding information plays a major role in explaining the episodic memory deficits experienced by patients with aMCI.Discussion: The present study applying the ISDA reveals great sensitivity and specificity of the encoding deficit index when identifying aMCI. As aMCI constitutes a risk factor to develop Alzheimer's disease, the current findings also confirm the need to concentrate on encoding deficits as an early diagnostic sign of cognitive decline.enghttp://creativecommons.org/licenses/by-nc-nd/4.0/Encoding deficitEpisodic memoryISDA methodNeuropsychologyaMCIresearch articleAttribution-NonCommercial-NoDerivatives 4.0 International3072377411108-11410.1016/j.dadm.2018.12.002Alzheimer'S & Dementia (Amsterdam, Netherlands)open access2-s2.0-85060273868L2001489486