Flores, José CarlosGràcia-Lavedan, EstherBenavente, YolandaAmiano, PilarRomaguera, DoraCostas, LauraRobles, ClaudiaGonzalez-Barca, Evade la Banda, EsmeraldaAlonso, EstherAymerich, MartaCampo, EliasDierssen-Sotos, TrinidadMarcos-Gragera, RafaelRodríguez-Suárez, Marta MaríaSolans, MartaGimeno, EvaGarcia Martin, PalomaAragones, NuriaShivappa, NitinHebert, James RPollan-Santamaria, MarinaKogevinas, Manolisde Sanjose, SilviaCastaño-Vinyals, GemmaCasabonne, Delphine2020-01-162020-01-162019-12-23Nutrients. 2019 Dec 23;12(1). pii: E48.2072-6643http://hdl.handle.net/20.500.13003/12398http://hdl.handle.net/20.500.12105/8903Chronic inflammation plays a role in the development of chronic lymphocytic leukaemia (CLL), and diet might modulate chronic inflammation. This study aims to evaluate the association between the dietary inflammatory index (DII®) and CLL. A total of 366 CLL cases and 1643 controls of the Spanish multicase-control (MCC) Spain study were included. The inflammatory potential of the diet was assessed using the energy-adjusted dietary inflammatory index (E-DII) based on 30 items from a validated semi-quantitative food frequency questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using logistic regression models controlling for potential confounders. Overall, a modest, non-statistically significant, positive association was observed between CLL and E-DII scores (OR for a one-unit increase in E-DII: 1.05 (CI 95%: 0.99, 1.12), p-value = 0.09 and by tertiles: ORT2vsT1: 1.20 (CI 95%: 0.90, 1.59); OR T3vsT1: 1.21 (CI 95%: 0.90, 1.62), p trend = 0.21). These results were independent from disease severity (p-het: 0.70), time from diagnosis (p-het: 0.67) and CLL treatment received (p-het: 0.56). No interactions were detected. In conclusion, the consumption of a diet with high pro-inflammatory components was not significantly associated with CLL. Changes towards a more pro-inflammatory dietary pattern in younger generations not included here warrant future research.engVoRhttp://creativecommons.org/licenses/by/4.0/MCC Spain studyCancerCase-control studyChronic lymphocytic leukaemiaDietary inflammatory indexNutritionAgedCase-Control StudiesEnergy IntakeSpainHumansInflammationMiddle AgedDietMaleSeverity of Illness IndexFemaleRisk FactorsOdds RatioLeukemia, Lymphocytic, Chronic, B-CellDiet RecordsAtribución 4.0 Internacional318780041214810.3390/nu120100482072-6643Nutrientsopen accessRegistros de DietaOportunidad RelativaFemeninoDietaMasculinoFactores de RiesgoHumanosPersona de Mediana EdadIngestión de EnergíaInflamaciónAncianoÍndice de Severidad de la EnfermedadLeucemia Linfocítica Crónica de Células BEspañaEstudios de Casos y Controles2-s2.0-85077310957516825500048L2003420862