Peinado, HéctorZhang, HaiyingMatei, Irina RCosta-Silva, BrunoHoshino, AyukoRodrigues, GoncaloPsaila, BethanKaplan, Rosandra NBromberg, Jacqueline FKang, YibinBissell, Mina JCox, Thomas RGiaccia, Amato JErler, Janine THiratsuka, SachieGhajar, Cyrus MLyden, David2018-06-012018-06-012017-05Nat Rev Cancer.2018; 17(5):302-317.1474-175Xhttp://hdl.handle.net/20.500.12105/6097It is well established that organs of future metastasis are not passive receivers of circulating tumour cells, but are instead selectively and actively modified by the primary tumour before metastatic spread has even occurred. Sowing the 'seeds' of metastasis requires the action of tumour-secreted factors and tumour-shed extracellular vesicles that enable the 'soil' at distant metastatic sites to encourage the outgrowth of incoming cancer cells. In this Review, we summarize the main processes and new mechanisms involved in the formation of the pre-metastatic niche.engVoRhttp://creativecommons.org/licenses/by-nc-sa/4.0/BREAST-CANCER METASTASISMONOCYTE CHEMOATTRACTANT PROTEIN-1TUMOR BARRIER PERMEABILITYGROWTH-FACTOR RECEPTOR-1C CHEMOKINE RECEPTOR-5COLLAGEN CROSS-LINKINGSENTINEL LYMPH-NODESE-SELECTIN LIGAND-1PREMETASTATIC NICHE;CANCER PROSTATEAnimalsHumansNeoplasm MetastasisNeoplasmsNeoplastic Cells, CirculatingTumor MicroenvironmentAtribución-NoComercial-CompartirIgual 4.0 Internacional28303905175302-31710.1038/nrc.2017.61474-1768Nature reviews. Cancer