Shyam, SangeethaGarcía-Gavilán, Jesús FranciscoPaz-Graniel, IndiraGaforio, José JMartínez-González, Miguel ÁngelCorella, DoloresMartínez, J AlfredoAlonso-Gómez, Ángel MWärnberg, JuliaVioque, JesusRomaguera, DoraLópez-Miranda, JoséEstruch, RamonTinahones, Francisco JLapetra, JoséSerra-Majem, LluisBueno-Cavanillas, AuroraTur, Josep ASanchez, Vicente MartinPintó, XavierMatía-Martín, PilarVidal, JosepVazquez, ClotildeDaimiel, LidiaRos, EmilioFernandez-Aranda, FernandoNishi, Stephanie KGarcia-Regata, OscarToledo, EstefaníaAsensio, Eva MCastañer, OlgaGarcia-Rios, AntonioTorres-Collado, LauraGómez-Gracia, EnriqueZulet, M AngelesGoñi-Ruiz, NuriaCasas, RosaCano-Ibáñez, NaomiTojal-Sierra, LucasGómez-Perez, A MSorli, Jose VCinza-Sanjurjo, SergioMartín-Peláez, SandraPeña-Orihuela, Patricia JOncina-Canovas, AlejandroPerez-Araluce, RafaelZomeño, María DoloresChaplin, AliceDelgado-Rodríguez, MiguelBabio, NancyFitó, MontserratSalas-Salvado, Jordi2024-10-092024-10-092023-10-13Shyam S, García-Gavilán JF, Paz-Graniel I, Gaforio JJ, Martínez-González MÁ, Corella D, et al. Association of adiposity and its changes over time with COVID-19 risk in older adults with overweight/obesity and metabolic syndrome: a longitudinal evaluation in the PREDIMED-Plus cohort. BMC Med. 2023 Oct 13;21(1):390.https://hdl.handle.net/20.500.13003/20007https://hdl.handle.net/20.500.12105/23594Background: Cross-sectionally, older age and obesity are associated with increased coronavirus disease-2019 (COVID-19) risk. We assessed the longitudinal associations of baseline and changes in adiposity parameters with COVID-19 incidence in older adults at high cardiovascular risk. Methods: This analysis included 6874 men and women (aged 55-75 years) with overweight/obesity and metabolic syndrome in the PREDIMED-Plus lifestyle intervention trial for cardiovascular risk reduction. Body weight, body-mass-index (BMI), waist circumference, waist-to-height ratio (WHtR), and a body shape index (ABSI) were measured at baseline and annual follow-up visits. COVID-19 was ascertained by an independent Event Committee until 31 December 2021. Cox regression models were fitted to evaluate the risk of COVID-19 incidence based on baseline adiposity parameters measured 5-6 years before the pandemic and their changes at the visit prior to censoring. Results: At the time of censoring, 653 incident COVID-19 cases occurred. Higher baseline body weight, BMI, waist circumference, and WHtR were associated with increased COVID-19 risk. During the follow-up, every unit increase in body weight (HRadj (95%CI): 1.01 (1.00, 1.03)) and BMI (HRadj: 1.04 (1.003, 1.08)) was associated with increased COVID-19 risk. Conclusions: In older adults with overweight/obesity, clinically significant weight loss may protect against COVID-19. Trial registration: This study is registered at the International Standard Randomized Controlled Trial (ISRCT; http://www.isrctn.com/ISRCTN89898870).enghttp://creativecommons.org/licenses/by/4.0/Metabolic SyndromeAgedBody WeightHumansMiddle AgedObesityMaleFemaleRisk FactorsAdiposityBody Mass IndexCOVID-19OverweightWaist Circumferenceresearch articleAtribución 4.0 Internacional3783367821139010.1186/s12916-023-03079-z1741-7015BMC medicineopen accessÍndice de Masa CorporalSíndrome MetabólicoFemeninoCOVID-19MasculinoCircunferencia de la CinturaFactores de RiesgoHumanosObesidadPersona de Mediana EdadAncianoPeso CorporalSobrepesoAdiposidad2-s2.0-851742454001088480600001L2026077722