Dosil, Sara GRodríguez-Galán, AnaSánchez-Madrid, FranciscoFernández-Messina, Lola2023-09-042023-09-042022-12-23Int J Mol Sci. 2022 Dec 23;24(1):250.http://hdl.handle.net/20.500.12105/16401MicroRNAs (miRNAs) act as master regulators of gene expression in homeostasis and disease. Despite the rapidly growing body of evidence on the theranostic potential of restoring miRNA levels in pre-clinical models, the translation into clinics remains limited. Here, we review the current knowledge of miRNAs as T-cell targeting immunotherapeutic tools, and we offer an overview of the recent advances in miRNA delivery strategies, clinical trials and future perspectives in RNA interference technologies.engVoRhttp://creativecommons.org/licenses/by/4.0/MicroRNAsT-LymphocytesRNA InterferencePrecision MedicineImmunotherapyAtribución 4.0 Internacional3661370624110.3390/ijms240102501422-0067International journal of molecular sciencesopen access