Guzman-Fulgencio, MariaBerenguer, JuanMicheloud, DarielaFernandez-Rodriguez, AmandaGarcia-Alvarez, MonicaJimenez-Sousa, Maria AngelesBellón, José MaríaCampos, YolandaCosín, JaimeAldámiz-Echevarria, TeresaCatalán, PilarLópez, Juan CarlosResino, Salvador2020-07-012020-07-012013-10J Antimicrob Chemother . 2013 Oct;68(10):2349-57.http://hdl.handle.net/20.500.12105/10623There is substantial interindividual variability in the rate and extent of CD4+ T cell recovery after starting combination antiretroviral therapy (cART). The aim of our study was to determine whether mitochondrial DNA (mtDNA) haplogroups are associated with recovery of CD4+ in HIV-infected patients on cART. We carried out a retrospective study on 275 cART-naive patients with CD4+ counts <350 cells/mm(3), who were followed-up during at least 24 months after initiating cART. mtDNA genotyping was performed by Sequenom's MassARRAY platform. Patients within cluster JT and haplogroup J had a lower chance of achieving a CD4+ count ≥500 cells/mm(3) than patients within cluster HV and haplogroup H [hazard ratio (HR) = 0.68 (P = 0.058) and HR = 0.48 (P = 0.010), respectively]. The time of follow-up during which the CD4+ count was ≥500 cells/mm(3) was longer in haplogroups HV and H than in haplogroups JT and J [20 months versus 6.2 months (P = 0.029) and 20 months versus 0 months (P = 0.024), respectively]. Additionally, haplogroups HV and H had greater chances of achieving a CD4+ count ≥500 cells/mm(3) during at least 12, 36, 48 and 60 months post-cART initiation compared with patients within haplogroups JT and J. Patients within haplogroup T only had a lesser chance of achieving a CD4+ count ≥500 cells/mm(3) during at least 48 months and 60 months post-cART initiation. European mitochondrial haplogroups might influence CD4+ recovery in HIV-infected patients following initiation with cART. Haplogroups J and T appear to be associated with a worse profile of CD4+ recovery, whereas haplogroup H was associated with a better CD4+ reconstitution.engAMhttp://creativecommons.org/licenses/by-nc-sa/4.0/Antiretroviral Therapy, Highly ActiveAdultAnti-Retroviral AgentsCD4 Lymphocyte CountCD4-Positive T-LymphocytesDNA, MitochondrialFemaleFollow-Up StudiesHIV InfectionsHaplotypesHumansMaleMiddle AgedRetrospective StudiesAtribución-NoComercial-CompartirIgual 4.0 Internacional2374995068102349-5710.1093/jac/dkt2061460-2091The Journal of antimicrobial chemotherapyopen access