Delgado, Ana CMaldonado-Soto, Angel RSilva-Vargas, VioletaMizrak, Dogukanvon Känel, ThomasTan, Kelly RPaul, AlexMadar, AvivCuervo, HenarKitajewski, JanLin, Chyuan-ShengDoetsch, Fiona2024-01-172024-01-172021-06-11Science. 2021 Jun 11;372(6547):1205-1209.http://hdl.handle.net/20.500.12105/17205Quiescent neural stem cells (NSCs) in the adult mouse ventricular-subventricular zone (V-SVZ) undergo activation to generate neurons and some glia. Here we show that platelet-derived growth factor receptor beta (PDGFRβ) is expressed by adult V-SVZ NSCs that generate olfactory bulb interneurons and glia. Selective deletion of PDGFRβ in adult V-SVZ NSCs leads to their release from quiescence, uncovering gliogenic domains for different glial cell types. These domains are also recruited upon injury. We identify an intraventricular oligodendrocyte progenitor derived from NSCs inside the brain ventricles that contacts supraependymal axons. Together, our findings reveal that the adult V-SVZ contains spatial domains for gliogenesis, in addition to those for neurogenesis. These gliogenic NSC domains tend to be quiescent under homeostasis and may contribute to brain plasticity.engVoRhttp://creativecommons.org/licenses/by-nc-nd/4.0/Adult Stem CellsAnimalsAstrocytesAxonsCell DifferentiationCell DivisionCerebral VentriclesEpendymaFemaleGene Expression ProfilingHomeostasisLateral VentriclesMaleMiceNeural Stem CellsNeurogenesisNeurogliaOlfactory BulbOligodendrogliaReceptor, Platelet-Derived Growth Factor betaAttribution-NonCommercial-NoDerivatives 4.0 Internacional341126923726547120510.1126/science.abg84671095-9203Science (New York, N.Y.)open access